Outer Retinal Thickness Is Associated With Cognitive Function in Normal Aging to Intermediate Age-Related Macular Degeneration

被引：3

作者：

Owsley, Cynthia ^{[1
]}

McGwin Jr, Gerald ^{[1
]}

Swain, Thomas A. ^{[1
,2
]}

Clark, Mark E. ^{[1
]}

Thomas, Tracy N. ^{[1
]}

Goerdt, Lukas ^{[1
,3
]}

Sloan, Kenneth R. ^{[1
]}

Trittschuh, Emily H. ^{[4
,5
]}

Jiang, Yu ^{[6
,7
]}

Owen, Julia P. ^{[6
,7
]}

Lee, Cecilia S. ^{[6
,7
]}

Curcio, Christine A. ^{[1
]}

机构：

[1] Univ Alabama Birmingham, Heersink Sch Med, Dept Ophthalmol & Visual Sci, 1720 Univ Blvd,Suite 609, Birmingham, AL 35233 USA

[2] Univ Alabama Birmingham, Sch Publ Hlth, Dept Epidemiol, Birmingham, AL USA

[3] Univ Bonn, Dept Ophthalmol, Bonn, Germany

[4] VA Puget Sound Geriatr Res Educ & Clin Ctr, Seattle, WA USA

[5] Univ Washington, Sch Med, Dept Psychiat & Behav Sci, Seattle, WA USA

[6] Univ Washington, Sch Med, Dept Ophthalmol, Seattle, WA USA

[7] Roger & Angie Karalis Johnson Retina Ctr, Seattle, WA USA

来源：

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE | 2024年 / 65卷 / 05期

基金：

美国国家卫生研究院;

关键词：

age-related macular degeneration; aging; optical coherence tomography; cognition; NERVE-FIBER LAYER; ALZHEIMERS-DISEASE; IMPAIRMENT; ABNORMALITIES; ADAPTATION; BIOMARKERS; PATHOLOGY; DECLINE;

D O I：

10.1167/iovs.65.5.16

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

PURPOSE. Research on Alzheimer's disease (AD) and precursor states demonstrates a thinner retinal nerve fiber layer (NFL) compared to age-similar controls. Because AD and agerelated macular degeneration (AMD) both impact older adults and share risk factors, we asked if retinal layer thicknesses, including NFL, are associated with cognition in AMD. METHODS. Adults >= 70 years with normal retinal aging, early AMD, or intermediate AMD per Age-Related Eye Disease Study (AREDS) nine-step grading of color fundus photography were enrolled in a cross-sectional study. Optical coherence tomography (OCT) volumes underwent 11-line segmentation and adjustments by a trained operator. Evaluated thicknesses reflect the vertical organization of retinal neurons and two vascular watersheds: NFL, ganglion cell layer-inner plexiform layer complex (GCL-IPL), inner retina, outer retina (including retinal pigment epithelium-Bruch's membrane), and total retina. Thicknesses were area weighted to achieve mean thickness across the 6-mm-diameter Early Treatment of Diabetic Retinopathy Study (ETDRS) grid. Cognitive status was assessed by the National Institutes of Health Toolbox cognitive battery for fluid and crystallized cognition. Correlations estimated associations between cognition and thicknesses, adjusting for age. RESULTS. Based on 63 subjects (21 per group), thinning of the outer retina was significantly correlated with lower cognition scores (P < 0.05). No other retinal thickness variables were associated with cognition. CONCLUSIONS. Only the outer retina (photoreceptors, supporting glia, retinal pigment epithelium, Bruch's membrane) is associated with cognition in aging to intermediate AMD; NFL was not associated with cognition, contrary to AD-associated condition reports. Early and intermediate AMD constitute a retinal disease whose earliest, primary impact is in the outer retina. Our findings hint at a unique impact on the brain from the outer retina in persons with AMD.

引用

页数：9

共 67 条

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