Investigating the Impacts of Diet, Supplementation, Microbiota, Gut-Brain Axis on Schizophrenia: A Narrative Review

被引:2
作者
Zajkowska, Izabela [1 ]
Niczyporuk, Patrycja [1 ]
Urbaniak, Agata [1 ]
Tomaszek, Natalia [1 ]
Modzelewski, Stefan [1 ]
Waszkiewicz, Napoleon [1 ]
机构
[1] Med Univ Bialystok, Dept Psychiat, Pl Wolodyjowskiego 2, PL-15272 Bialystok, Poland
关键词
gut-brain axis; diet; schizophrenia; supplementation; microbiota; eating habits; neuroleptics; POLYUNSATURATED FATTY-ACIDS; N-ACETYL CYSTEINE; PLACEBO-CONTROLLED TRIAL; IRRITABLE-BOWEL-SYNDROME; WITHANIA-SOMNIFERA; GINKGO-BILOBA; DOUBLE-BLIND; VITAMIN-D; IMMUNE ACTIVATION; HELICOBACTER-PYLORI;
D O I
10.3390/nu16142228
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Schizophrenia is a disease with a complex etiology that significantly impairs the functioning of patients. In recent years, there has been increasing focus on the importance of the gut microbiota in the context of the gut-brain axis. In our study, we analyzed data on the gut-brain axis in relation to schizophrenia, as well as the impacts of eating habits, the use of various supplements, and diets on schizophrenia. Additionally, the study investigated the impact of antipsychotics on the development of metabolic disorders, such as diabetes, dyslipidemia, and obesity. There may be significant clinical benefits to be gained from therapies supported by supplements such as omega-3 fatty acids, B vitamins, and probiotics. The results suggest the need for a holistic approach to the treatment of schizophrenia, incorporating both drug therapy and dietary interventions.
引用
收藏
页数:36
相关论文
共 237 条
  • [81] The Microbiota-Gut-Brain Axis in Psychiatric Disorders
    Goralczyk-Binkowska, Aleksandra
    Szmajda-Krygier, Dagmara
    Kozlowska, Elzbieta
    [J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (19)
  • [82] Brain-derived neurotrophic factor levels in schizophrenia: a systematic review with meta-analysis
    Green, M. J.
    Matheson, S. L.
    Shepherd, A.
    Weickert, C. S.
    Carr, V. J.
    [J]. MOLECULAR PSYCHIATRY, 2011, 16 (09) : 960 - 972
  • [83] Inhibition of the NEMO/IKKβ association complex formation, a novel mechanism associated with the NF-κB activation suppression by Withania somnifera's key metabolite withaferin A
    Grover, Abhinav
    Shandilya, Ashutosh
    Punetha, Ankita
    Bisaria, Virendra S.
    Sundar, Durai
    [J]. BMC GENOMICS, 2010, 11
  • [84] Microglia Polarization From M1 to M2 in Neurodegenerative Diseases
    Guo, Shenrui
    Wang, Hui
    Yin, Yafu
    [J]. FRONTIERS IN AGING NEUROSCIENCE, 2022, 14
  • [85] Aqueous extract from the Withania somnifera leaves as a potential anti-neuroinflammatory agent: a mechanistic study
    Gupta, Muskan
    Kaur, Gurcharan
    [J]. JOURNAL OF NEUROINFLAMMATION, 2016, 13
  • [86] The relationship between schizophrenia and irritable bowel syndrome (IBS)
    Gupta, S
    Masand, PS
    Kaplan, D
    Bhandary, A
    Hendricks, S
    [J]. SCHIZOPHRENIA RESEARCH, 1997, 23 (03) : 265 - 268
  • [87] The Role of Serotonin Neurotransmission in Gastrointestinal Tract and Pharmacotherapy
    Guzel, Tomasz
    Mirowska-Guzel, Dagmara
    [J]. MOLECULES, 2022, 27 (05):
  • [88] The acute efficacy of antipsychotics in schizophrenia: a review of recent meta-analyses
    Haddad, Peter M.
    Correll, Christoph U.
    [J]. THERAPEUTIC ADVANCES IN PSYCHOPHARMACOLOGY, 2018, 8 (11) : 303 - 318
  • [89] Acute Gastrointestinal Infection Induces Long-Lived Microbiota-Specific T Cell Responses
    Hand, Timothy W.
    Dos Santos, Liliane M.
    Bouladoux, Nicolas
    Molloy, Michael J.
    Pagan, Antonio J.
    Pepper, Marion
    Maynard, Craig L.
    Elson, Charles O., III
    Belkaid, Yasmine
    [J]. SCIENCE, 2012, 337 (6101) : 1553 - 1556
  • [90] Linking early-life NMDAR hypofunction and oxidative stress inyschizophrenia pathogenesis
    Hardingham, Giles E.
    Do, Kim Q.
    [J]. NATURE REVIEWS NEUROSCIENCE, 2016, 17 (02) : 1 - 9