A Review of Atomic-Force Microscopy in Skin Barrier Function Assessment

被引:1
作者
Pereda, Jorge [1 ,2 ]
Khatib, Casper Milde [3 ]
Kezic, Sanja [4 ]
Christensen, Maria Oberlander [3 ]
Yang, Sara [5 ]
Thyssen, Jacob P. [3 ]
Chu, Chia-Yu [6 ,7 ]
Riethmuller, Christoph [8 ]
Liao, Hsien-Shun [9 ]
Akhtar, Imtisal [1 ,2 ]
Ungar, Benjamin [10 ]
Guttman-Yassky, Emma [10 ]
Haedersdal, Merete [11 ]
Hwu, En-Te [1 ,2 ]
机构
[1] Tech Univ Denmark, Danish Natl Res Fdn, Lyngby, Denmark
[2] Tech Univ Denmark, Villum Fdn Ctr Intelligent Drug Delivery & Sensing, Dept Hlth Technol, Lyngby, Denmark
[3] Univ Copenhagen, Bispebjerg & Frederiksberg Hosp, Dept Dermatol, Copenhagen, Denmark
[4] Amsterdam UMC, Coronel Inst Occupat Hlth, Amsterdam, Netherlands
[5] Univ Lubeck, Univ Hosp Schleswig Holstein, Dept Dermatol Allergol & Venereol, Lubeck, Germany
[6] Natl Taiwan Univ Hosp, Coll Med, Dept Dermatol, Taipei, Taiwan
[7] Natl Taiwan Univ, Coll Med, Taipei, Taiwan
[8] Serend Ip GmbH, Ctr Nanotechnol, Munster, Germany
[9] Natl Taiwan Univ, Dept Mech Engn, Taipei, Taiwan
[10] Icahn Sch Med Mt Sinai, Kimberly & Eric J Waldman Dept Dermatol, New York, NY USA
[11] Univ Copenhagen, Bispebjerg Hosp, Copenhagen, Denmark
基金
新加坡国家研究基金会;
关键词
Atomic-force microscopy; Atopic dermatitis; Corneocyte morphology; Skin barrier function; INVESTIGATOR GLOBAL ASSESSMENT; ATOPIC-DERMATITIS; STRATUM-CORNEUM; FILAGGRIN BREAKDOWN; ECZEMA AREA; IN-VIVO; CORNEOCYTES; SEVERITY; CELL; SURFACE;
D O I
10.1016/j.jid.2024.04.005
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Skin barrier function (SBF) disorders are a class of pathologies that affect a significant portion of the world population. These disorders cause skin lesions with intense itch, impacting patients' physical and psychological well-being as well as their social functioning. It is in the interest of patients that their disorder be monitored closely while under treatment to evaluate the effectiveness of the ongoing therapy and any potential adverse reactions. Symptom-based assessment techniques are widely used by clinicians; however, they carry some limitations. Techniques to assess skin barrier impairment are critical for understanding the nature of the disease and for helping personalize treatment. This review recalls the anatomy of the skin barrier and describes an atomic-force microscopy approach to quantitatively monitor its disorders and their response to treatment. We review a panel of studies that show that this technique is highly relevant for SBF disorder research, and we aim to motivate its adoption into clinical settings.
引用
收藏
页码:2136 / 2144
页数:9
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