The Role of Anti-Mullerian Hormone in Ovarian Function

被引：0
作者：
Yildiz, Sena [1 ]
Moolhuijsen, Loes M. E. [1 ]
Visser, Jenny A. [1 ]
机构：
[1] Univ Med Ctr Rotterdam, Erasmus MC, Dept Internal Med, POB 2040, NL-3000 CA Rotterdam, Netherlands
来源：
SEMINARS IN REPRODUCTIVE MEDICINE | 2024年 / 42卷 / 01期
关键词：
anti-M & uuml; llerian hormone; folliculogenesis; signaling; genetics; INHIBITING SUBSTANCE; FOLLICLE DEVELOPMENT; II RECEPTOR; GONADAL DEVELOPMENT; GENE POLYMORPHISM; MLLERIAN HORMONE; GRANULOSA-CELLS; ANDROGEN LEVELS; ESTROUS-CYCLE; DUCT SYNDROME;
D O I：
10.1055/s-0044-1786732
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Anti-Mullerian hormone (AMH) is a member of the transforming growth factor beta (TGF beta) superfamily, whose actions are restricted to the endocrine-reproductive system. Initially known for its role in male sex differentiation, AMH plays a role in the ovary, acting as a gatekeeper in folliculogenesis by regulating the rate of recruitment and growth of follicles. In the ovary, AMH is predominantly expressed by granulosa cells of preantral and antral follicles (i.e., post primordial follicle recruitment and prior to follicle-stimulating hormone (FSH) selection). AMH signals through a BMP-like signaling pathway in a manner distinct from other TGF beta family members. In this review, the latest insights in AMH processing, signaling, its regulation of spatial and temporal expression pattern, and functioning in folliculogenesis are summarized. In addition, effects of AMH variants on ovarian function are reviewed.
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收藏
页码：15 / 24
页数：10
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