Isoprenoid flavonoids isolated from Sophora davidii and their activities induces apoptosis and autophagy in HT29 cells

被引：2
|
作者：
Yuan, Jing-Jing [1 ,2 ]
Meng, Yu-Fan [1 ,2 ]
Zhang, Mao-Sheng [1 ,2 ,3 ,4 ]
Guo, Da-Le [5 ]
Yang, Jian-Wen [1 ,2 ,3 ,4 ]
Dong, Min-Jian [1 ,2 ,3 ,4 ]
Sun, Cheng-Xin [1 ,2 ,3 ,4 ]
Xiao, Shi-Ji [1 ,2 ,3 ,4 ]
机构：
[1] Zunyi Med Univ, Key Lab Basic Pharmacol Guizhou Prov, Zunyi 563000, Peoples R China
[2] Zunyi Med Univ, Sch Pharm, Zunyi 563000, Peoples R China
[3] Zunyi Med Univ, Key Lab Basic Pharmacol, Minist Educ, Zunyi 563000, Peoples R China
[4] Zunyi Med Univ, Joint Int Res Lab Ethnomed, Minist Educ, Zunyi 563000, Peoples R China
[5] Chengdu Univ Tradit Chinese Med, State Key Lab Southwestern Chinese Med Resources, Chengdu 611137, Peoples R China
来源：
FITOTERAPIA | 2024年 / 175卷
基金：
中国国家自然科学基金;
关键词：
Isoprenoid flavonoids; Sophora davidii; Apoptosis; Autophagy; HT29; FLAVANONES; CONSTITUENTS;
D O I：
10.1016/j.fitote.2024.105945
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Four previously undescribed isoprenoid flavonoids ( 2 - 5 ) were isolated from Sophora davidii , along with five known analogues. The structures of the compounds were established through comprehensive analysis of spectroscopic data, including HRESIMS, 1D and 2D NMR, and absolute configurations determined by theoretical calculations, including ECD and NMR calculation. The cytotoxic effects of the isolated compounds on human HT29 colon cancer cells were evaluated using the MTT assay, compound 1 exhibited cytotoxicity against human HT29 colon cancer cells with an IC 50 value of 8.39 +/- 0.09 mu M. Studies conducted with compound 1 in HT29 cells demonstrated that it may induce apoptosis and autophagy in HT29 by promoting the phosphorylation of P38 MAPK and inhibiting the phosphorylation of Erk MAPK.
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页数：8
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