Cyano-Hydrol green derivatives: Expanding the 9-cyanopyronin-based resonance Raman vibrational palette

被引：4

作者：

Fujioka, Hiroyoshi ^{[1
]}

Murao, Yuta ^{[1
]}

Okinaka, Momoko ^{[2
]}

Spratt, Spencer John ^{[3
]}

Shou, Jingwen ^{[4
]}

Kawatani, Minoru ^{[1
,5
]}

Kojima, Ryosuke ^{[5
]}

Tachibana, Ryo ^{[2
]}

Urano, Yasuteru ^{[2
,5
]}

Ozeki, Yasuyuki ^{[3
,4
]}

Kamiya, Mako ^{[1
,5
,6
]}

机构：

[1] Tokyo Inst Technol, Dept Life Sci & Technol, 4259 Nagatsuta Cho Midori Ku, Yokohama, Kanagawa 2268501, Japan

[2] Univ Tokyo, Grad Sch Pharmaceut Sci, 7-3-1 Hongo,Bunkyo Ku, Tokyo 1130033, Japan

[3] Univ Tokyo, Res Ctr Adv Sci & Technol, 4-6-1 Komaba,Meguro Ku, Tokyo 1538904, Japan

[4] Univ Tokyo, Dept Elect Engn & Informat Syst, 7-3-1 Hongo,Bunkyo Ku, Tokyo 1138656, Japan

[5] Univ Tokyo, Grad Sch Med, 7-3-1 Hongo,Bunkyo Ku, Tokyo 1130033, Japan

[6] Tokyo Inst Technol, Inst Innovat Res, Res Ctr Autonomous Syst Meterial ASMat, 4259 Nagatsuta Cho Midori Ku, Yokohama, Kanagawa 2268501, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2024年 / 106卷

关键词：

Michler 's Hydrol Blue; Resonance Raman; Stimulated Raman scattering; Spontaneous Raman scattering; Multiplex detection; STIMULATED RAMAN; PHOTOPHYSICS; SCATTERING; PROBES; BLUE;

D O I：

10.1016/j.bmcl.2024.129757

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

9-cyanopyronin is a promising scaffold that exploits resonance Raman enhancement to enable sensitive, highly multiplexed biological imaging. Here, we developed cyano-Hydrol Green (CN-HG) derivatives as resonance Raman scaffolds to expand the color palette of 9-cyanopyronins. CN-HG derivatives exhibit sufficiently long wavelength absorption to produce strong resonance Raman enhancement for near-infrared (NIR) excitation, and their nitrile peaks are shifted to a lower frequency than those of 9-cyanopyronins. The fluorescence of CN-HG derivatives is strongly quenched due to the lack of the 10th atom, unlike pyronin derivatives, and this enabled us to detect spontaneous Raman spectra with high signal -to -noise ratios. CN-HG derivatives are powerful candidates for high performance vibrational imaging.

引用

页数：6

共 29 条

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