Identification of biomarkers and potential therapeutic targets for pancreatic cancer by proteomic analysis in two prospective cohorts

被引：0

作者：

Lyu, Jingjing ^{[1
,2
]}

Jiang, Minghui ^{[1
,2
]}

Zhu, Ziwei ^{[1
,2
]}

Wu, Hongji ^{[1
,2
]}

Kang, Haonan ^{[1
,2
]}

Hao, Xingjie ^{[1
,2
]}

Cheng, Shanshan ^{[1
,2
]}

Guo, Huan ^{[1
,3
]}

Shen, Xia ^{[4
]}

Wu, Tangchun ^{[1
,3
]}

Chang, Jiang ^{[1
,5
]}

Wang, Chaolong ^{[1
,2
]}

机构：

[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, State Key Lab Environm Hlth Incubating,Minist Educ, Wuhan, Peoples R China

[2] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Epidemiol & Biostat, Wuhan, Peoples R China

[3] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Occupat & Environm & Hlth, Wuhan, Peoples R China

[4] Fudan Univ, Greater Bay Area Inst Precis Med Guangzhou, Guangzhou, Peoples R China

[5] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Hlth Toxicol, Wuhan, Peoples R China

来源：

CELL GENOMICS | 2024年 / 4卷 / 06期

基金：

国家重点研发计划;

关键词：

GENOME-WIDE ASSOCIATION; C-REACTIVE PROTEIN; MENDELIAN RANDOMIZATION; SUSCEPTIBILITY LOCI; GENETIC-VARIANTS; RISK; INFLAMMATION; EXPRESSION; INSULIN; METAANALYSIS;

D O I：

10.1016/j.xgen.2024.100561

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Pancreatic cancer (PC) is the deadliest malignancy due to late diagnosis. Aberrant alterations in the blood proteome might serve as biomarkers to facilitate early detection of PC. We designed a nested case -control study of incident PC based on a prospective cohort of 38,295 elderly Chinese participants with -5.7 years' follow-up. Forty matched case -control pairs passed the quality controls for the proximity extension assay of 1,463 serum proteins. With a lenient threshold of p < 0.005, we discovered regenerating family member 1A (REG1A), REG1B, tumor necrosis factor (TNF), and phospholipase A2 group IB (PLA2G1B) in association with incident PC, among which the two REG1 proteins were replicated using the UK Biobank Pharma Proteomics Project, with effect sizes increasing steadily as diagnosis time approaches the baseline. Mendelian randomization analysis further supported the potential causal effects of REG1 proteins on PC. Taken together, circulating REG1A and REG1B are promising biomarkers and potential therapeutic targets for the early detection and prevention of PC.

引用

页数：12

共 71 条

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