Role of Yme1 in mitochondrial protein homeostasis: from regulation of protein import, OXPHOS function to lipid synthesis and mitochondrial dynamics

被引:2
作者
Kan, Kwan Ting [1 ]
Wilcock, Joel [1 ]
Lu, Hui [1 ]
机构
[1] Univ Manchester, Manchester Acad Hlth Sci Ctr, Sch Biol Sci, Fac Biol Med & Hlth, Manchester M13 9PT, Lancs, England
关键词
AAA PROTEASES; INTERMEMBRANE SPACE; INNER MEMBRANE; CYTOCHROME-C; YEAST YME1; DEGRADATION; DISEASE; ATP; TRANSPORT; ACCUMULATION;
D O I
10.1042/BST20240450
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Mitochondria are essential organelles of eukaryotic cells and thus mitochondrial proteome is under constant quality control and remodelling. Yme1 is a multi-functional protein and subunit of the homo-hexametric complex i-AAA proteinase. Yme1 plays vital roles in the regulation of mitochondrial protein homeostasis and mitochondrial plasticity, ranging from substrate degradation to the regulation of protein functions involved in mitochondrial protein biosynthesis, energy production, mitochondrial dynamics, and lipid biosynthesis and signalling. In this mini review, we focus on discussing the current understanding of the roles of Yme1 in mitochondrial protein import via TIM22 and TIM23 pathways, oxidative phosphorylation complex function, as well as mitochondrial lipid biosynthesis and signalling, as well as a brief discussion of the role of Yme1 in modulating mitochondrial dynamics.
引用
收藏
页码:1539 / 1548
页数:10
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