Leniolisib: a drug providing a promising avenue for the treatment of activated phosphoinositide 3-kinase δ syndrome (APDS)

被引：0

作者：

Ali, Anoshia ^{[1
]}

Qureshi, Amsal ^{[1
]}

Shigri, Anum Fatima ^{[1
]}

Alvi, Areesha Moiz ^{[1
]}

Malikzai, Abdullah ^{[2
]}

机构：

[1] Agha Khan Univ Hosp AKU, Karachi, Pakistan

[2] Kabul Med Univ, Kabul, Afghanistan

来源：

ANNALS OF MEDICINE AND SURGERY | 2024年 / 86卷 / 07期

关键词：

PI3K-DELTA;

D O I：

10.1097/MS9.0000000000002189

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：3812 / 3813

页数：2

共 5 条

[1] Natural Course of Activated Phosphoinositide 3-Kinase Delta Syndrome in Childhood and Adolescence [J].

Bloomfield, Marketa ;

Klocperk, Adam ;

Zachova, Radana ;

Milota, Tomas ;

Kanderova, Veronika ;

Sediva, Anna .

FRONTIERS IN PEDIATRICS, 2021, 9

[2] PI3Kδ and primary immunodeficiencies (vol 16, pg 702, 2016) [J].

Lucas, Carrie L. ;

Chandra, Anita ;

Nejentsev, Sergey ;

Condliffe, Alison M. ;

Okkenhaug, Klaus .

NATURE REVIEWS IMMUNOLOGY, 2016, 16 (11) :715-715

[3] A randomized, placebo-controlled phase 3 trial of the PI3K8 inhibitor leniolisib for activated PI3K8 syndrome [J].

Rao, V. Koneti ;

Webster, Sharon ;

Sediva, Anna ;

Plebani, Alessandro ;

Schuetz, Catharina ;

Shcherbina, Anna ;

Conlon, Niall ;

Coulter, Tanya ;

Dalm, Virgil A. ;

Trizzino, Antonino ;

Zharankova, Yulia ;

Kulm, Elaine ;

Koerholz, Julia ;

Lougaris, Vassilios ;

Rodina, Yulia ;

Radford, Kath ;

Bradt, Jason ;

Kucher, Klaus ;

Relan, Anurag ;

Holland, Steven M. ;

Lenardo, Michael J. ;

Uzel, Gulbu .

BLOOD, 2023, 141 (09) :971-983

[4] Effective "activated PI3Kδ syndrome"-targeted therapy with the PI3Kd inhibitor leniolisib [J].

Rao, V. Koneti ;

Webster, Sharon ;

Dalm, Virgil A. S. H. ;

Sediva, Anna ;

van Hagen, P. Martin ;

Holland, Steven ;

Rosenzweig, Sergio D. ;

Christ, Andreas D. ;

Sloth, Birgitte ;

Cabanski, Maciej ;

Joshi, Aniket D. ;

de Buck, Stefan ;

Doucet, Julie ;

Guerini, Danilo ;

Kalis, Christoph ;

Pylvaenaeinen, Ilona ;

Soldermann, Nicolas ;

Kashyap, Anuj ;

Uzel, Gulbu ;

Lenardo, Michael J. ;

Patel, Dhavalkumar D. ;

Lucas, Carrie L. ;

Burkhart, Christoph .

BLOOD, 2017, 130 (21) :2307-2316

[5] Disorders Related to PI3Kδ Hyperactivation: Characterizing the Clinical and Immunological Features of Activated PI3-Kinase Delta Syndromes [J].

Redenbaugh, Vyanka ;

Coulter, Tanya .

FRONTIERS IN PEDIATRICS, 2021, 9

← 1 →