Circulating serotypes and genotypes of dengue virus in North India: An observational study

被引：3
作者：
Prakash, Om [1 ]
Verma, Anil Kumar [1 ]
Paliwal, Asutosh [1 ]
Abbas, Faisal [1 ]
Srivastava, Ashish Kumar [1 ]
Mishra, Vivek Kumar [1 ]
Radera, Shruti [1 ]
Jain, Amita [1 ]
机构：
[1] King Georges Med Univ, Dept Microbiol, Lucknow, India
来源：
JOURNAL OF VECTOR BORNE DISEASES | 2024年 / 61卷 / 01期
关键词：
Dengue Virus; Dengue fever; DENV-1; DENV-2; DENV-3; DENV-4; EMERGENCE; OUTBREAK; TYPE-3; DELHI;
D O I：
10.4103/0972-9062.392258
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Background & objectives: This study reports observation on circulating serotypes and genotypes of Dengue Virus in North India. Methods: Serum samples were obtained from suspected cases of dengue referred to the virus diagnostic laboratory during 2014 to 2022. All samples were tested for anti-dengue virus IgM antibodies and NS1Ag by ELISA. NS1Ag positive samples were processed for serotyping and genotyping. Results: Total 41,476 dengue suspected cases were referred to the laboratory of which 12,292 (29.6%) tested positive. Anti-Dengue Virus IgM antibodies, NS1Ag, both IgM and NS1Ag, were positive in 7007 (57.4%); 3200 (26.0%) and 2085 (16.0%) cases respectively. Total 762 strains were serotyped during 9-year period. DENV-1, DENV-2, DENV-3 and DENV-4 serotypes were found in 79 (10.37%), 506 (66.40%), 151 (19.82%) and 26 (3.41%) cases respectively. DENV-1, DENV-2 and DENV-3 were in circulation throughout. Total 105 strains were genotyped. Genotype IV of DENV-1 serotype was circulating till 2014 which was later replaced by genotype V. A distinct seasonality with increase in number of cases in post-monsoon period was seen. Interpretation & conclusion: DENV-1, DENV-2 and DENV-3 were found to be in circulation in North India. Predominant serotype/genotype changed at times, but not at regular intervals.
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页码：117 / 122
页数：6
相关论文
共 25 条
[1]   Emergence of new genotypes and lineages of dengue viruses during the 2012-15 epidemics in southern India [J].
Ahamed, Syed Fazil ;
Vivek, Rosario ;
Britto, Carl ;
Dias, Mary ;
Nayak, Kaustuv ;
Chandele, Anmol ;
Murali-Krishna, Kaja ;
Shet, Anita .
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 2019, 84 :S34-S43
[2]   Serotype and genotype diversity of dengue viruses circulating in India: a multi-centre retrospective study involving the Virus Research Diagnostic Laboratory Network in 2018 [J].
Alagarasu, K. ;
Patil, J. A. ;
Kakade, M. B. ;
More, A. M. ;
Yogesh, B. ;
Newase, P. ;
Jadhav, S. M. ;
Parashar, D. ;
Kaur, H. ;
Gupta, N. ;
Vijay, N. ;
Narayan, J. ;
Shah, P. S. .
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 2021, 111 :242-252
[3]   Co-circulation of all the four Dengue virus serotypes during 2018-2019: first report from Eastern Uttar Pradesh, India [J].
Behera, Sthita Pragnya ;
Bhardwaj, Pooja ;
Deval, Hirawati ;
Srivastava, Neha ;
Singh, Rajeev ;
Misra, Brij Ranjan ;
Agrawal, Awdhesh ;
Kavathekar, Asif ;
Kant, Rajni .
PEERJ, 2023, 11
[4]  
Bhatia Rajesh, 2013, WHO South East Asia J Public Health, V2, P23, DOI 10.4103/2224-3151.115830
[5]   Refining the Global Spatial Limits of Dengue Virus Transmission by Evidence-Based Consensus [J].
Brady, Oliver J. ;
Gething, Peter W. ;
Bhatt, Samir ;
Messina, Jane P. ;
Brownstein, John S. ;
Hoen, Anne G. ;
Moyes, Catherine L. ;
Farlow, Andrew W. ;
Scott, Thomas W. ;
Hay, Simon I. .
PLOS NEGLECTED TROPICAL DISEASES, 2012, 6 (08)
[6]   Emergence of the Asian genotype of DENV-1 in South India [J].
Cecilia, D. ;
Patil, J. A. ;
Kakade, M. B. ;
Walimbe, A. ;
Alagarasu, K. ;
Anukumar, B. ;
Abraham, A. .
VIROLOGY, 2017, 510 :40-45
[7]  
Dar L, 2006, EMERG INFECT DIS, V12, P352
[8]   SHORT REPORT Emergence of dengue virus type 4 (genotype I) in India [J].
Dash, P. K. ;
Sharma, S. ;
Srivastava, A. ;
Santhosh, S. R. ;
Parida, M. M. ;
Neeraja, M. ;
Subbalaxmi, M. V. S. ;
Lakshmi, V. ;
Rao, P. V. L. .
EPIDEMIOLOGY AND INFECTION, 2011, 139 (06) :857-861
[9]   Genetic characterization of dengue virus serotype 2 isolated from dengue fever outbreaks in eastern Uttar Pradesh and western Bihar, India [J].
Deval, Hirawati ;
Behera, Sthita P. ;
Agrawal, Awdhesh ;
Singh, Rajeev ;
Misra, Brijranjan ;
Janardhan, Vanka ;
Patil, Gajanan ;
Sah, Kamlesh ;
Kumar, Niraj ;
Singh, Ravishankar ;
Bondre, Vijay P. .
JOURNAL OF MEDICAL VIROLOGY, 2021, 93 (06) :3322-3329
[10]   Genotypic Differences in Dengue Virus Neutralization Are Explained by a Single Amino Acid Mutation That Modulates Virus Breathing [J].
Dowd, Kimberly A. ;
DeMaso, Christina R. ;
Pierson, Theodore C. .
MBIO, 2015, 6 (06)
123