Transdermal microneedles integrating biomimetic self-adjuvant particles for enhanced immunity

被引：4

作者：

Jiang, Min ^{[1
]}

Zhang, Yuandong ^{[1
]}

Zheng, Tao ^{[1
]}

Chang, Yu ^{[1
]}

Qiao, Nan ^{[1
]}

Qin, Ming ^{[1
]}

He, Penghui ^{[1
]}

He, Chunting ^{[1
]}

Du, Guangsheng ^{[1
]}

Merkel, Olivia M. ^{[2
,3
,4
,5
]}

Sun, Xun ^{[1
]}

机构：

[1] Sichuan Univ, West China Sch Pharm, Sichuan Engn Lab Plant Sourced Drug & Sichuan Res, Educ Minist,Key Lab Drug Targeting & Drug Delivery, Chengdu 610064, Peoples R China

[2] Ludwig Maximilians Univ Munchen, Dept Pharm Pharmaceut Technol & Biopharm, D-81377 Munich, Germany

[3] Helmholtz Munich, Inst Lung Hlth & Immun LHI, Munich, Germany

[4] Helmholtz Munich, Comprehens Pneumol Ctr CPC CPC M BioArch, Munich, Germany

[5] German Ctr Lung Res DZL, Munich, Germany

来源：

NANO TODAY | 2024年 / 58卷

基金：

中国国家自然科学基金; 中国博士后科学基金;

关键词：

Polymeric microneedles; Transdermal delivery; Self-adjuvant carriers; Glucan particles; Subunit vaccines; ALUMINUM-HYDROXIDE; DELIVERY-SYSTEM; VACCINE; MICROCAPSULES; NANOPARTICLES; DRUG; MIGRATION; RELEASE; PEPTIDE;

D O I：

10.1016/j.nantod.2024.102443

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Optimal exposure and interaction of subunit antigens with the immune system are crucial for effective immunity. The epidermis and dermis, which harbor a significant population of antigen-presenting cells (APCs) and are broadly connected to the lymphatic system, serve as ideal sites for immunization to fulfill these objectives. However, the stratum corneum barrier severely hinders transdermal delivery of antigens. Here, we developed a transdermal platform integrating yeast-derived biomimetic glucan particles (GPs) and polymeric microneedles to overcome the hurdles and induce effective immunity. GPs served as carriers for encapsulating antigens in a pathogen-like manner. The antigen-loaded particles were concentrated within the tips of polymeric microneedle to solidify as tiny reservoirs, while the needle bodies were shaped using a fast-dissolving matrix. This tip-loaded approach enabled rapid administration for better compliance, followed by an extended antigen release at administration sites, aiming for recruiting more APCs. This microscale platform capacitated a multi-functional approach for subunit vaccine development by optimizing both delivery carriers and dosage forms with modulated release mechanisms to enhance antigen exposure and interaction, thereby promoting effective humoral and cellular immunity.

引用

页数：19

共 49 条

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