T-2 toxin-induced damage to articular cartilage in rats coincided with impaired autophagy linked to the HIF-1 α /AMPK signaling axis

被引：5

作者：

Qi, Fang ^{[1
,2
,3
]}

Cui, Si -Lu ^{[1
,2
,3
]}

Zhang, Bing ^{[1
,2
,3
,4
]}

Li, Hao-Nan ^{[1
,2
,3
]}

Yu, Jun ^{[1
,2
,3
]}

机构：

[1] Harbin Med Univ, Inst Kashin Beck Dis Control & Prevent, Chinese Ctr Dis Control & Prevent, Harbin 150081, Heilongjiang, Peoples R China

[2] Harbin Med Univ, Harbin Med Univ 23618504, Natl Hlth Commiss, Heilongjiang Prov Lab Trace Element & Human Hlth, Harbin 150081, Peoples R China

[3] Harbin Med Univ, Harbin Med Univ 23618504, Educ Bur Heilongjiang Prov, Key Lab Etiol & Epidemiol,Heilongjiang Prov Lab Tr, Harbin 150081, Peoples R China

[4] Beihua Univ, Sch Publ Hlth, Jilin 132013, Jilin, Peoples R China

来源：

TOXICON | 2024年 / 243卷

基金：

中国国家自然科学基金;

关键词：

T-2; toxin; HIF-1; alpha/AMPK; Autophagy; Articular cartilage; Rats; Chronic; CHONDROCYTES; EXPRESSION; HIF-1-ALPHA; APOPTOSIS; OSTEOARTHRITIS; INVOLVEMENT; PROTECTS; PATHWAY; CELLS;

D O I：

10.1016/j.toxicon.2024.107735

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

T-2 toxin is one of the most toxic mycotoxins. People are primarily exposed to T-2 toxin through the consumption of spoiled food, typically over extended periods and at low doses. T-2 toxin can cause damage to articular cartilage. However, the exact mechanism is not fully understood. In this experiment, 36 male rats were divided into a control group, a solvent control group, and a T-2 toxin group. The rats in the T-2 toxin group were orally administered the toxin at a dosage of 100 ng/g BW/Day. The damage to articular cartilage and key proteins associated with the autophagy process and the HIF-1 alpha/AMPK signaling axis was assessed at 4, 8, 12, and 16 weeks. Our findings indicate that T-2 toxin-induced damage to articular cartilage in rats coincided with impaired autophagy linked to the HIF-1 alpha/AMPK signaling pathway. This study offers novel insights into the precise mechanism underlying T-2 toxin-induced damage to articular cartilage.

引用

页数：10

共 41 条

[1] Human and animal dietary exposure to T-2 and HT-2 toxin [J].