Transition-Metal-Free (Hetero)arylsulfonylation of 1-Iodopyrrolo[1,2-a]quinoxalines

被引：0

作者：

Ca, Thuy T. ^{[1
,2
,3
]}

Le, Khanh T. M. ^{[2
,4
]}

Nguyen, Tung T. ^{[1
,2
,4
]}

Chau, Ngoc D. Q. ^{[1
,2
]}

机构：

[1] Ho Chi Minh City Univ Technol HCMUT, Fac Chem Engn, 268 Ly Thuong Kiet,Dist 10, Ho Chi Minh City, Vietnam

[2] Vietnam Natl Univ Ho Chi Minh City, Ho Chi Minh City, Vietnam

[3] Univ Med & Pharm, Fac Basic Sci, Ho Chi Minh City, Vietnam

[4] VNU HCM Key Lab Funct Organ Mat, Ho Chi Minh City, Vietnam

来源：

CHEMISTRYSELECT | 2024年 / 9卷 / 26期

关键词：

pyrrolo[1,2-a]quinoxaline; sulfonylation; arylsulfinate; metal-free; heteroarene; DERIVATIVES;

D O I：

10.1002/slct.202401948

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We describe herein a method for transition-metal-free (hetero)arylsulfonylation of 1-iodopyrrolo[1,2-a]quinoxalines with sodium arylsulfinates. The corresponding aryl iodides were in situ prepared from eletrophilic iodination of C1-H bonds in pyrrolo[1,2-a]quinoxalines with N-iodosuccinimide. The ensuing sulfonylation only required DMSO as solvent and completed after 15 min. Many arylsulfinates bearing chloro, bromo, methylsufonyl, acetamide, and nitro groups were competent substrates. Heteroarylsulfonylation of pyrrolo[1,2-a]quinoxalines were also feasible.

引用

页数：5

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