Biopharmaceutical beamline TLS 15A1 for macromolecular crystallography at the National Synchrotron Radiation Research Center

被引：1

作者：

Chiang, Cheng-Hung ^{[1
]}

Chou, Chung-Kuang ^{[1
]}

Tseng, Chien-Chang ^{[1
]}

Chen, Yi-Hui ^{[1
]}

Liu, Yi-Chun ^{[1
]}

Huang, Chen-Ying ^{[1
]}

Chao, Chun-Hsiung ^{[1
]}

Huang, Chun-Hsiang ^{[1
]}

机构：

[1] Natl Synchrotron Radiat Res Ctr, Expt Facil Div, Prot Diffract Grp, 101 Hsin Ann Rd,Hsinchu Sci Pk, Hsinchu 300092, Taiwan

来源：

JOURNAL OF THE CHINESE CHEMICAL SOCIETY | 2024年 / 71卷 / 07期

关键词：

macromolecular crystallography experiment; National Synchrotron Radiation Research Center; TLS; 15A1; DATA-COLLECTION; SILICON MONOCHROMATOR; X-RAYS; DIFFRACTION; PERFORMANCE; BINDING; SYSTEM; DOMAIN; ERRORS;

D O I：

10.1002/jccs.202400111

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Synchrotron protein crystallography (PX) remains an indispensable tool for uncovering the atomic structures of biomolecules. TLS 15A1, operated by the protein diffraction group of NSRRC, has been accessible to both academic and industrial users since January 2013. This beamline is energy-tunable within a range between 5.6 and 15.5 keV, which is suitable for phasing experiments. Over the past 11 years, TLS 15A1 has supported 657 projects and facilitated 1523 experiments across 41,656 h of beamtime. This article describes the beamline layout, studies of factors influencing data quality, and significant scientific contributions.

引用

页码：721 / 731

页数：11