Progress in approved drugs from natural product resources

被引：128
作者：
Luo, Zhongwen [1 ]
Yin, Fucheng [1 ]
Wang, Xiaobing [1 ]
Kong, Lingyi [1 ]
机构：
[1] China Pharmaceut Univ, Sch Tradit Chinese Pharm, State Key Lab Nat Med, Nanjing 211198, Peoples R China
来源：
CHINESE JOURNAL OF NATURAL MEDICINES | 2024年 / 22卷 / 03期
基金：
中国国家自然科学基金;
关键词：
New drugs; Natural products; Structural modification; CYCLOSPORINE-A; ANISODAMINE; HOMOHARRINGTONINE; CLARITHROMYCIN; TELITHROMYCIN; GALANTHAMINE; AZITHROMYCIN; PHARMACOLOGY; TACROLIMUS; LOVASTATIN;
D O I：
10.1016/S1875-5364(24)60582-0
中图分类号：
R [医药、卫生];
学科分类号：
10 ;
摘要：
Natural products (NPs) have consistently played a pivotal role in pharmaceutical research, exerting profound impacts on the treatment of human diseases. A significant proportion of approved molecular entity drugs are either directly derived from NPs or indirectly through modifications of NPs. This review presents an overview of NP drugs recently approved in China, the United States, and other countries, spanning various disease categories, including cancers, cardiovascular and cerebrovascular diseases, central nervous system disorders, and infectious diseases. The article provides a succinct introduction to the origin, activity, development process, approval details, and mechanism of action of these NP drugs.
引用
收藏
页码：195 / 211
页数：17
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