Artificial Intelligence in The Management of Neurodegenerative Disorders

被引:12
作者
Dhankhar, Sanchit [1 ,2 ]
Mujwar, Somdutt [1 ]
Garg, Nitika [1 ,2 ]
Chauhan, Samrat [1 ]
Saini, Monika [3 ]
Sharma, Prerna [4 ]
Kumar, Suresh [2 ]
Sharma, Satish Kumar [5 ]
Kamal, Mohammad Amjad [6 ,7 ,8 ,9 ,10 ]
Rani, Nidhi [1 ]
机构
[1] Chitkara Univ, Chitkara Coll Pharm, Chitkara, Punjab, India
[2] Ganpati Inst Pharm, Bilaspur 135102, Haryana, India
[3] Maharishi Markandeshwar Deemed Univ, Ambala 133207, Haryana, India
[4] Guru Gobind Singh Coll Pharm, Yamunanagar 135001, Haryana, India
[5] Glocal Univ, Glocal Sch Pharm, Saharanpur, Uttar Pradesh, India
[6] Sichuan Univ, West China Hosp, Frontiers Sci Ctr Dis Related Mol Network, Inst Syst Genet, Chengdu, Peoples R China
[7] King Abdulaziz Univ, King Fahd Med Res Ctr, Jeddah 21589, Saudi Arabia
[8] Daffodil Int Univ, Fac Allied Hlth Sci, Dept Pharm, Dhaka 1207, Bangladesh
[9] Enzymoics, 7 Peterlee Pl, Hebersham, NSW 2770, Australia
[10] Novel Global Community Educ Fdn, Hebersham, Australia
关键词
Computational approaches; neurodegenerative diseases; drug-design; AI; Alzheimer's; Huntington's; Parkinson's; frontotemporal dementia; LEARNING-MODELS; DISEASE;
D O I
10.2174/0118715273266095231009092603
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Neurodegenerative disorders are characterized by a gradual but irreversible loss of neurological function. The ability to detect and treat these conditions successfully is crucial for ensuring the best possible quality of life for people who suffer from them. The development of effective new methods for managing and treating neurodegenerative illnesses has been made possible by recent developments in computer technology. In this overview, we take a look at the prospects for applying computational approaches, such as drug design, AI, ML, and DL, to the treatment of neurodegenerative diseases. To review the current state of the field, this article discusses the potential of computational methods for early disease detection, quantifying disease progression, and understanding the underlying biological mechanisms of neurodegenerative diseases, as well as the challenges associated with these approaches and potential future directions. Moreover, it delves into the creation of computational models for the individualization of care for neurodegenerative diseases. The article concludes with suggestions for future studies and clinical applications, highlighting the advantages and disadvantages of using computational techniques in the treatment of neurodegenerative diseases.
引用
收藏
页码:931 / 940
页数:10
相关论文
共 100 条
[31]  
Gisevius B., 2019, Neuroforum, V25, P39, DOI [10.1515/nf-2018-0013, DOI 10.1515/NF-2018-0013]
[32]   Predicting Survival of Patients with Amyotrophic Lateral Sclerosis at Presentation: A 15-Year Experience [J].
Gordon, Paul H. ;
Salachas, Francois ;
Lacomblez, Lucette ;
Le Forestier, Nadine ;
Pradat, Pierre-Francois ;
Bruneteau, Gaelle ;
Elbaz, Alexis ;
Meininger, Vincent .
NEURODEGENERATIVE DISEASES, 2013, 12 (02) :81-90
[33]   A Computational Approach to Investigate TDP-43 RNA-Recognition Motif 2 C-Terminal Fragments Aggregation in Amyotrophic Lateral Sclerosis [J].
Grassmann, Greta ;
Miotto, Mattia ;
Di Rienzo, Lorenzo ;
Salaris, Federico ;
Silvestri, Beatrice ;
Zacco, Elsa ;
Rosa, Alessandro ;
Tartaglia, Gian Gaetano ;
Ruocco, Giancarlo ;
Milanetti, Edoardo .
BIOMOLECULES, 2021, 11 (12)
[34]   Brain aging and neurodegeneration: from a mitochondrial point of view [J].
Grimm, Amandine ;
Eckert, Anne .
JOURNAL OF NEUROCHEMISTRY, 2017, 143 (04) :418-431
[35]  
Gupta S., 2021, Curr. Res. Behav. Sci, V2, P100049, DOI [DOI 10.1016/J.CRBEHA.2021.100049, 10.1016/j.crbeha.2021.100049]
[36]   Indene-Derived Hydrazides Targeting Acetylcholinesterase Enzyme in Alzheimer's: Design, Synthesis, and Biological Evaluation [J].
Gupta, Shraddha Manish ;
Behera, Ashok ;
Jain, Neetesh K. ;
Kumar, Devendra ;
Tripathi, Avanish ;
Tripathi, Shailesh Mani ;
Mujwar, Somdutt ;
Patra, Jeevan ;
Negi, Arvind .
PHARMACEUTICS, 2023, 15 (01)
[37]   Application of In silico Methods in the Design of Drugs for Neurodegenerative Diseases [J].
Haider, Mohamad ;
Chauhan, Anjali ;
Tariq, Sana ;
Pathak, Dharam Pal ;
Siddiqui, Nadeem ;
Ali, Soni ;
Pottoo, Faheem Hyder ;
Ali, Ruhi .
CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2021, 21 (11) :995-1011
[38]  
Halli-Tierney AD, 2020, AM FAM PHYSICIAN, V102, P679
[39]  
Heifetz A, 2018, METHODS MOL BIOL, V1705, P375, DOI 10.1007/978-1-4939-7465-8_19
[40]   Vocal Feature Extraction-Based Artificial Intelligent Model for Parkinson's Disease Detection [J].
Hoq, Muntasir ;
Uddin, Mohammed Nazim ;
Park, Seung-Bo .
DIAGNOSTICS, 2021, 11 (06)