Alzheimer's disease: insights into pathology, molecular mechanisms, and therapy

被引：51
作者：
Zheng, Qiuyang [1 ,2 ]
Wang, Xin [1 ,2 ]
机构：
[1] Xiamen Univ, Shenzhen Res Inst, Shenzhen 518057, Peoples R China
[2] Xiamen Univ, Affiliated Hosp 1, Inst Neurosci, Sch Med ,Dept Neurol,State Key Lab Cellular Stress, Xiamen 361005, Peoples R China
来源：
PROTEIN & CELL | 2024年 / 16卷 / 02期
基金：
中国国家自然科学基金; 国家重点研发计划;
关键词：
Alzheimer's disease; pathophysiology; risk factors; biomarkers; prevention; AMYLOID PRECURSOR PROTEIN; APOLIPOPROTEIN-E GENOTYPE; TRAUMATIC BRAIN-INJURY; SIMPLEX-VIRUS TYPE-1; PLASMA NEUROFILAMENT LIGHT; CEREBRAL BETA-AMYLOIDOSIS; PAIRED HELICAL FILAMENTS; GROWTH-FACTOR EXPRESSION; GENOME-WIDE ASSOCIATION; CRYO-EM STRUCTURES;
D O I：
10.1093/procel/pwae026
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Alzheimer's disease (AD), the leading cause of dementia, is characterized by the accumulation of amyloid plaques and neurofibrillary tangles in the brain. This condition casts a significant shadow on global health due to its complex and multifactorial nature. In addition to genetic predispositions, the development of AD is influenced by a myriad of risk factors, including aging, systemic inflammation, chronic health conditions, lifestyle, and environmental exposures. Recent advancements in understanding the complex pathophysiology of AD are paving the way for enhanced diagnostic techniques, improved risk assessment, and potentially effective prevention strategies. These discoveries are crucial in the quest to unravel the complexities of AD, offering a beacon of hope for improved management and treatment options for the millions affected by this debilitating disease.
引用
收藏
页码：83 / 120
页数：38
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