Metabolic vulnerabilities in cancer: A new therapeutic strategy

被引：4
作者：
El-Tanani, Mohamed [1 ]
Rabbani, Syed Arman [1 ]
El-Tanani, Yahia [2 ]
Matalka, Ismail I. [3 ,4 ]
机构：
[1] RAK Med & Hlth Sci Univ, RAK Coll Pharm, Ras Al Khaymah, U Arab Emirates
[2] St Georges Univ London, Med Sch, Cranmer Terrace, London, England
[3] RAK Med & Hlth Sci Univ, Ras Al Khaymah, U Arab Emirates
[4] Jordan Univ Sci & Technol, Dept Pathol & Microbiol, Irbid, Jordan
来源：
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY | 2024年 / 201卷
关键词：
Cancer metabolism; Metabolic reprogramming; Tumor heterogeneity; Adaptive resistance; Glycolysis inhibitors; Glutaminase inhibitors; Personalized medicine; Predictive biomarkers; GLUTAMINASE INHIBITOR CB-839; TUMOR MICROENVIRONMENT; SYNTHETIC LETHALITY; HETEROGENEITY; COMBINATION; 2-DEOXY-D-GLUCOSE; GLUTAMINOLYSIS; GLYCOLYSIS; CHALLENGES; HALLMARKS;
D O I：
10.1016/j.critrevonc.2024.104438
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Cancer metabolism is now a key area for therapeutic intervention, targeting unique metabolic reprogramming crucial for tumor growth and survival. This article reviews the therapeutic potential of addressing metabolic vulnerabilities through glycolysis and glutaminase inhibitors, which disrupt cancer cell metabolism. Challenges such as tumor heterogeneity and adaptive resistance are discussed, with strategies including personalized medicine and predictive biomarkers to enhance treatment efficacy. Additionally, integrating diet and lifestyle changes with metabolic targeting underscores a holistic approach to improving therapy outcomes. The article also examines the benefits of incorporating these strategies into standard care, highlighting the potential for more tailored, safer treatments. In conclusion, exploiting metabolic vulnerabilities promises a new era in oncology, positioning metabolic targeting at the forefront of personalized cancer therapy and transforming patient care.
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页数：12
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