Astrocyte mitochondria: Potential therapeutic targets for epilepsy

被引：2
作者：
Chen, Lu [1 ]
Yang, Wenqian [1 ]
Yang, Fei [1 ]
Xu, Tingwan [1 ]
Yu, Yanying [1 ]
Wu, Qian [1 ]
Han, Yanbing [1 ]
机构：
[1] Kunming Med Univ, Affiliated Hosp 1, Dept Neurol 1, 295 Xi Chang Rd, Kunming 650032, Yunnan, Peoples R China
来源：
HELIYON | 2024年 / 10卷 / 09期
基金：
中国国家自然科学基金;
关键词：
Epilepsy; Astrocyte mitochondria; Glutamate; Calcium homeostasis; Adenosine triphosphate; RESPIRATION; MECHANISMS; INJURY;
D O I：
10.1016/j.heliyon.2024.e29950
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Epilepsy is a chronic, relapsing neurological disorder, and current treatments focus primarily on neurons, yet one-third of patients still develop drug-resistant epilepsy. Therefore, there is an urgent need to explore new therapeutic targets. Interestingly, astrocytes can transfer their healthy mitochondria into neighboring neurons, thus preventing neuronal damage. Astrocyte mitochondria have been shown to have a therapeutic role in stroke and neurodegenerative diseases. However, their therapeutic effect in epilepsy and its related mechanisms have been less studied. In this review, we mainly summarize the regulatory role of astrocyte mitochondria in glutamate, calcium ion, and adenosine triphosphate (ATP) homeostasis and outline the protective role of astrocyte mitochondria in nervous system diseases, revealing a new target for epilepsy treatment.
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页数：9
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