Natural rubber latex-based biomaterials for drug delivery and regenerative medicine: Trends and directions

被引：12

作者：

Marques, Paulo Augusto Chagas ^{[1
]}

Guerra, Nayrim Brizuela ^{[2
]}

dos Santos, Lindomar Soares ^{[3
]}

Mussagy, Cassamo Ussemane ^{[4
]}

Brasil, Giovana Sant 'Ana Pegorin ^{[5
,6
]}

Burd, Betina Sayeg ^{[5
,6
]}

Su, Yanjin ^{[5
]}

Sasaki, Josana Carla da Silva ^{[5
,6
]}

Scontri, Mateus ^{[5
]}

Lopes Filho, Paulo Eduardo de Lima ^{[5
]}

Silva, Glaucio Ribeiro ^{[7
]}

Miranda, Matheus Carlos Romeiro ^{[8
]}

Ferreira, Ernando Silva ^{[9
]}

Primo, Fernando Lucas ^{[10
]}

Fernandes, Mariza Aires ^{[10
]}

Crotti, Antonio Eduardo Miller ^{[3
]}

He, Siqi ^{[11
]}

Forster, Samuel ^{[11
]}

Ma, Changyu ^{[11
,12
]}

de Barros, Natan Roberto ^{[11
]}

de Mendonca, Ricardo Jose ^{[13
]}

Jucaud, Vadim ^{[11
]}

Li, Bingbing ^{[11
,13
]}

Herculano, Rondinelli Donizetti ^{[5
,11
,13
]}

Floriano, Juliana Ferreira ^{[2
,5
,14
]}

机构：

[1] Univ Fed Sao Carlos, Dept Chem Engn, Rodovia Washington Luis Km 235, BR-13560970 Sao Carlos, SP, Brazil

[2] Sao Paulo State Univ UNESP, Sch Sci, BR-17033360 Bauru, SP, Brazil

[3] Univ Sao Paulo, Fac Philosophy Sci & Letters Ribeirao Preto, 3900 Bandeirantes Ave, BR-14040901 Ribeirao Preto, SP, Brazil

[4] Pontificia Univ Catolica Valparaiso, Escuela Agron, Fac Ciencias Agron & Alimentos, Valparaiso, Chile

[5] Sao Paulo State Univ UNESP, Bioengn & Biomat Grp, Sch Pharmaceut Sci, Araraquara, SP, Brazil

[6] Sao Paulo State Univ UNESP, Postgrad Program Biotechnol, Inst Chem, BR-14800060 Araraquara, SP, Brazil

[7] Fed Inst Educ Sci & Technol Minas Gerais, S-N Sao Luiz Gonzaga St, BR-35577010 Formiga, MG, Brazil

[8] Fed Univ Sao Paulo UNIFESP, Inst Environm Chem & Pharmaceut Sci, Rua Prof Artur Riedel 275, BR-09972270 Diadema, SP, Brazil

[9] State Univ Feira Santana UEFS, Dept Phys, S-N Transnordestina Highway, BR-44036900 Feira De Santana, BA, Brazil

[10] Sao Paulo State Univ UNESP, Fac Pharmaceut Sci, Dept Biotechnol & Bioproc Engn, Bionanomat & Bioengn Grp, BR-14800903 Sao Paulo, Brazil

[11] Terasaki Inst Biomed Innovat TIBI, 11507 W Olymp Blvd, Los Angeles, CA 90064 USA

[12] Fed Univ Triangulo Mineiro UFTM, Dept Biochem Pharmacol & Physiol, Uberaba, MG, Brazil

[13] Calif State Univ, Auton Res Ctr, STEAHM, Northridge, CA 91324 USA

[14] Imperial Coll London, Natl Heart & Lung Inst, London SW7 2AZ, England

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2024年 / 267卷

基金：

巴西圣保罗研究基金会;

关键词：

Controlled release; Drug delivery; Nanoparticles; Natural rubber latex; Regenerative medicine; Wound healing; OF-THE-ART; HEVEA-BRASILIENSIS; METALLIC NANOPARTICLES; BACTERIAL CELLULOSE; OXIDE NANOPARTICLES; CONTROLLED-RELEASE; CALCIUM-PHOSPHATE; GREEN SYNTHESIS; MEMBRANES; BONE;

D O I：

10.1016/j.ijbiomac.2024.131666

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Natural Rubber Latex (NRL) has shown to be a promising biomaterial for use as a drug delivery system to release various bioactive compounds. It is cost-effective, easy to handle, biocompatible, and exhibits pro-angiogenic and pro -healing properties for both soft and hard tissues. NRL releases compounds following burst and sustained release kinetics, exhibiting first -order release kinetics. Moreover, its pore density can be adjusted for tailored kinetics profiles. In addition, biotechnological applications of NRL in amblyopia, smart mattresses, and neovaginoplasty have demonstrated success. This comprehensive review explores NRL 's diverse applications in biotechnology and biomedicine, addressing challenges in translating research into clinical practice. Organized into eight sections, the review emphasizes NRL 's potential in wound healing, drug delivery, and metallic nanoparticle synthesis. It also addresses the challenges in enhancing NRL 's physical properties and discusses its interactions with the human immune system. Furthermore, examines NRL 's potential in creating wearable medical devices and biosensors for neurological disorders. To fully explore NRL 's potential in addressing important medical conditions, we emphasize throughout this review the importance of interdisciplinary research and collaboration. In conclusion, this review advances our understanding of NRL 's role in biomedical and biotechnological applications, offering insights into its diverse applications and promising opportunities for future development.

引用

页数：18

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