NGAL in the Development of Acute Kidney Injury in a Murine Model of Remote Ischaemic Preconditioning and Liver Ischaemia Reperfusion

被引：5

作者：

Platt, Esther ^{[1
]}

Robertson, Francis ^{[1
]}

Al-Rashed, Ali ^{[2
]}

Klootwijk, Riko ^{[2
]}

Hall, Andrew ^{[3
]}

Quaglia, Alberto ^{[3
]}

Salama, Alan ^{[2
]}

Heptinstall, Lauren ^{[3
]}

Davidson, Brian ^{[1
]}

机构：

[1] UCL, Div Surg & Intervent Sci, London NW3 2PF, England

[2] UCL, Dept Renal Med, Royal Free Hosp, London NW3 2PF, England

[3] Royal Free London NHS Fdn Trust, Dept Cellular Pathol, London NW3 2QG, England

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2024年 / 25卷 / 10期

关键词：

ischaemia reperfusion; acute kidney injury; remote ischaemic preconditioning; GELATINASE-ASSOCIATED LIPOCALIN; ISCHEMIA/REPERFUSION INJURY; HEPATIC ISCHEMIA; PREDICTION; PERFUSION; PROTECTS; TRIAL;

D O I：

10.3390/ijms25105061

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Acute kidney injury (AKI) is common following liver transplantation and is associated with liver ischeamia reperfusion (IR) injury. The purpose of this study was to use a mouse model of liver IR injury and AKI to study the role of Neutrophil Gelatinase Associated Lipocalin (NGAL), a biomarker of AKI, in liver IR injury and AKI. We demonstrate an adapted, reproducible model of liver IR injury and AKI in which remote ischemic preconditioning (RIPC) by repeated episodes of hindleg ischemia prior to liver IR reduced the severity of the IR injury. In this model, serum NGAL at 2 h post reperfusion correlated with AKI development early following IR injury. This early rise in serum NGAL was associated with hepatic but not renal upregulation of NGAL mRNA, suggesting NGAL production in the liver but not the kidney in the early phase post liver IR injury.

引用

页数：16

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