A comprehensive review of recent advances in chronic pancreatitis

被引:0
作者
Mao, Sheng-Han [1 ,2 ]
Zou, Wen-Bin [1 ,2 ]
Mao, Xiao-Tong [1 ,2 ]
Li, Zhao-Shen [1 ,2 ]
Liao, Zhuan [1 ,2 ]
机构
[1] Naval Med Univ, Changhai Hosp, Dept Gastroenterol, 168 Changhai Rd, Shanghai 200433, Peoples R China
[2] Shanghai Inst Pancreat Dis, Shanghai, Peoples R China
关键词
Chronic pancreatitis; Diagnosis; Endoscopy; Etiology; Mechanism; Surgery; MULTIPLE PLASTIC STENTS; LONG-TERM OUTCOMES; QUALITY-OF-LIFE; BILIARY STRICTURES; SURGICAL DRAINAGE; RECURRENT ACUTE; ALCOHOL-ABUSE; METAL STENT; PAIN; DIAGNOSIS;
D O I
10.1097/JP9.0000000000000161
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Chronic pancreatitis (CP) is a multifaceted disorder influenced by environmental and genetic factors, with smoking and alcohol consumption being major contributors. Recent developments encompass the advent of innovative transgenic models and the identification of susceptibility genes, shedding light on the genetic aspect of CP. The pathogenesis of this disease involves a complex interplay of pancreatic acinar cell dysfunction, inflammatory reactions, and fibrosis. Current research delves into understanding these molecular mechanisms. Pain, a pivotal symptom of CP, has been increasingly studied to develop effective therapeutic interventions. Diagnostic advancements, including endoscopic ultrasound, radiomics, and blood-based markers, have shown potential in enhancing early CP detection. Moreover, recent clinical trials have optimized treatment approaches, such as pancreatic stone fragmentation, stent placement, and decision-making between endoscopic and surgical procedures. Emerging therapies, including chemical pancreatectomy and gene therapy, present promising opportunities for improved CP management.
引用
收藏
页码:45 / 52
页数:8
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