Effects of Smilax China L. extracts on Hyperuricemia chicken model via inhibiting xanthine oxidase activity

被引：1

作者：

Yan, Mingen ^{[1
]}

Zheng, Xiaoman ^{[1
]}

Lin, Yongshi ^{[1
]}

Zheng, Xirui ^{[1
]}

Xi, Kailun ^{[1
]}

Gao, Yun ^{[1
]}

Wang, Huiting ^{[1
]}

Li, Yaoxing ^{[1
]}

Liu, Cui ^{[1
,2
]}

机构：

[1] South China Agr Univ, Coll Vet Med, Guangzhou 510642, Guangdong, Peoples R China

[2] Guangdong Technol Res Ctr Tradit Chinese Vet Med &, Guangzhou 510642, Guangdong, Peoples R China

来源：

POULTRY SCIENCE | 2024年 / 103卷 / 08期

关键词：

Smilax China L. extract; hyperuricemia; xanthine oxidase inhibition; kidney injury; URIC-ACID; GOUT; EPIDEMIOLOGY; EXCRETION;

D O I：

10.1016/j.psj.2024.103887

中图分类号：

S8 [畜牧、动物医学、狩猎、蚕、蜂];

学科分类号：

0905 ;

摘要：

Hyperuricemia (HUA) is a metabolic disorder caused by excessive production of uric acid (UA) or impaired uric acid metabolism. Smilax China L . has a wide range of pharmacological activities such as immunomodulatory, anti-in flammatory, and antioxidant. Its roots and rhizomes have been widely used for the treatment of HUA. However, its mechanisms for treating HUA and reducing renal impairment have not been fully elucidated. In the present study, we evaluated the effect of Smilax China L . extract (SC) on UA metabolism and further explored its mechanism of action by feeding a high -calcium and high -protein diet to chickens to induce a model of HUA in chickens. SC signi ficantly reduced serum UA levels and improved renal function in hyperuricemic chickens. Meanwhile, SC was able to inhibit the activity of xanthine oxidase (XOD) in vivo and in vitro, reducing the production of uric acid. In addition, SC was able to increase the expression of Breast Cancer Resistance Protein (BCRP) in the kidney and ileum and increase uric acid excretion. Therefore, our results suggest that SC may be a candidate for anti-hyperuricemia.

引用

页数：17

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