Pre-hospital evaluation of chest pain patients using the modified HEART-score: rationale and design

被引：0
作者：
Azzahhafi, Jaouad [1 ]
Yin, Chan Pin [1 ]
Epping, Mirjam [2 ]
Bofarid, Hajar [1 ]
Rikken, Sem A. O. F. [1 ]
Verhagen, Thijs [3 ,4 ]
Boomars, Rene [3 ]
Radstok, Anja [3 ]
Houtgraaf, Jaco [2 ]
Bikker, Angela [5 ,6 ]
ten Berg, Jurrien M. [1 ,7 ]
机构：
[1] St Antonius Hosp, Dept Cardiol, NL-3435 CM Nieuwegein, Netherlands
[2] Diakonessenhuis Hosp, Dept Cardiol, NL-3582 KE Utrecht, Netherlands
[3] Regionale Ambulance Voorziening Utrecht, NL-3723 BC Utrecht, Netherlands
[4] St Antonius Hosp, Dept Emergency Med, Nieuwegein, Netherlands
[5] Saltro Unilabs, Dept Clin Chem, NL-3565 CE Utrecht, Netherlands
[6] St Antonius Hosp, Dept Clin Chem, Nieuwegein, Netherlands
[7] Univ Med Ctr Maastricht, Dept Cardiol, NL-6229 HX Maastricht, Netherlands
来源：
FUTURE CARDIOLOGY | 2024年 / 20卷 / 5-6期
关键词：
cardiac troponin; HEART-score; high-sensitive cardiac troponin; NSTE-ACS; point-of-care testing; pre-hospital; POINT-OF-CARE; ANALYTICAL PERFORMANCE; CLINICAL VALIDATION; EMERGENCY-ROOM; CLASSIFICATION; ALGORITHM; ASSAY;
D O I：
10.1080/14796678.2024.2356995
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Background: This study assesses how ambulance paramedics using the modified HEART-score with a point-of-care cardiac troponin (cTn) compare to the emergency physicians using the modified HEART-score with a high-sensitive cTn (hs-cTn) in patients with suspected non-ST-elevation acute coronary syndrome (NSTE-ACS), focusing on interobserver agreement and diagnostic performance. Methods: In this prospective multicenter cohort, we compare four cTn testing strategies (serial point of care and hs-cTn cTn measurement) with and without the HEART-score. Outcomes include the HEART-score's interobserver agreement, NSTE-ACS at discharge, major adverse cardiovascular events (MACE) after 30 days, and diagnostic accuracy of the different strategies. Conclusion: The POPular HEART study aims to improve NSTE-ACS diagnostic pathways, promoting pre-hospital detection and ruling out of NSTE-ACS to minimize unnecessary hospitalizations and associated costs. Clinical Trial Registration: NCT04851418 (ClinicalTrials.gov)
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页码：241 / 250
页数：10
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