Might maintenance therapy be discontinued once clinical remission is achieved in ANCA-associated vasculitis?

被引：2

作者：

Roccatello, Dario ^{[1
,2
,3
]}

Padoan, Roberto ^{[4
]}

Sciascia, Savino ^{[1
,2
,3
]}

Iorio, Luca ^{[4
]}

Riogh, Eithne Nic An ^{[5
]}

Little, Mark A. ^{[5
]}

机构：

[1] Univ Turin, San Giovanni Bosco Hub Hosp, Ctr Immuno Rheumatol & Rare Dis CMID, Coordinating Ctr Interreg Network Rare Dis Piedmon, I-10154 Turin, Italy

[2] San Giovanni Bosco Hub Hosp, Ctr Immuno Rheumatol & Rare Dis CMID, Coordinating Ctr Interreg Network Rare Dis Piedmon, ASL Citta Torino, Turin, Italy

[3] Univ Torino, Turin, Italy

[4] Padova Univ, Dept Med DIMED, Rheumatol Unit, Padua, Italy

[5] Trinity Coll Dublin, Trinity Translat Med Inst, Trinity Kidney Ctr, Sch Med, Dublin, Ireland

来源：

AUTOIMMUNITY REVIEWS | 2024年 / 23卷 / 01期

关键词：

ANCA vasculitis; Relapse; Stopping therapy; Off therapy; Maintenance therapy rituximab; ANTIBODY-ASSOCIATED VASCULITIS; B-CELL DEPLETION; RITUXIMAB; CYCLOPHOSPHAMIDE; RELAPSE; INDUCTION; NEPHRITIS; OUTCOMES; RISK; PROTOCOL;

D O I：

10.1016/j.autrev.2023.103438

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) encompasses a group of rare, multisystem autoimmune disorders characterised by the occurrence of inflammation and damage to small blood vessels, leading to a wide range of clinical manifestations. They include granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA). Outcomes for patients with MPA and GPA have been transformed over recent years. However, the establishment of effective maintenance therapy aiming to balance the risks of disease relapse with those related to prolonged immunosuppression has become a clinical priority. This review aims to explore two differing perspectives on this unsolved problem. Pros and Cons of the following approaches will be discussed: "Biomarker-guided personalised approach on top of generic maintenance strategy guidelines " or "ANCA specificity -related personalised maintenance treatment after intensive B -cell depletion "?

引用

页数：5

共 53 条

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