Brain-Derived Neurotrophic Factor, Nociception, and Pain

被引：22
作者：
Merighi, Adalberto [1 ]
机构：
[1] Univ Turin, Dept Vet Sci, I-10095 Turin, Italy
来源：
BIOMOLECULES | 2024年 / 14卷 / 05期
关键词：
BDNF; nociception; pain; neurons; glia; presynaptic mechanisms; postsynaptic mechanisms; LTP; neuropeptides; DORSAL-ROOT GANGLION; LONG-TERM POTENTIATION; PRIMARY AFFERENT NEURONS; PRIMARY SENSORY NEURONS; FACTOR VAL66MET POLYMORPHISM; DIRECT-CURRENT STIMULATION; GELATINOSA LAMINA-II; SPINAL-CORD-INJURY; NEUROPATHIC PAIN; CENTRAL SENSITIZATION;
D O I：
10.3390/biom14050539
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
This article examines the involvement of the brain-derived neurotrophic factor (BDNF) in the control of nociception and pain. BDNF, a neurotrophin known for its essential role in neuronal survival and plasticity, has garnered significant attention for its potential implications as a modulator of synaptic transmission. This comprehensive review aims to provide insights into the multifaceted interactions between BDNF and pain pathways, encompassing both physiological and pathological pain conditions. I delve into the molecular mechanisms underlying BDNF's involvement in pain processing and discuss potential therapeutic applications of BDNF and its mimetics in managing pain. Furthermore, I highlight recent advancements and challenges in translating BDNF-related research into clinical practice.
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页数：49
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