Green innovation is a critical support to combat climate change arising from greenhouse gas emissions. Based on an environmental framework defined as the Stochastic Impacts by Regression on Population, Affluence, and Technology (STIRPAT) model, this study aimed to examine the impact of green innovation (GI), per capita GDP (PGDP), population density (PD), environmental regulations (ER), energy consumption (EC), and industrial structure upgrading (ISU) on CO2 emissions (CO2e). For this purpose, a sample dataset covering the 30 provincial regions in mainland China from 2005 to 2019 was analyzed using the Fixed Effects and System Generalized Method of Moment (SYS-GMM) Methodology. The data analysis indicated that CO2e in the current period were further exacerbated by the agglomeration effect of CO2e from the previous period. The empirical results showed that GI, ER, and ISU all exert a significant inhibitory effect on CO2e, whereas PGDP, PD, and EC had a positive effect on carbon emissions when dynamic relationships were analyzed. It is suggested that policymakers in China should focus on the decisive role of green technology application, environmental protection, and green transformation of industrial structure in curbing CO2e.