Structure-Inherent Tumor-Targeted IR-783 for Near-Infrared Fluorescence-Guided Photothermal Therapy

被引:1
|
作者
Park, Yoonbin [1 ,2 ]
Park, Min Ho [3 ,4 ]
Hyun, Hoon [1 ,2 ]
机构
[1] Chonnam Natl Univ, Med Sch, Dept Biomed Sci, Hwasun 58128, South Korea
[2] Chonnam Natl Univ, Biomed Sci Grad Program BMSGP, Hwasun 58128, South Korea
[3] Chonnam Natl Univ, Med Sch, Dept Surg, Hwasun 58128, South Korea
[4] Hwasun Hosp, Hwasun 58128, South Korea
基金
新加坡国家研究基金会;
关键词
IR-783; heptamethine cyanine dyes; photothermal therapy; near-infrared fluorescence imaging; tumor targeting; CANCER; DYE;
D O I
10.3390/ijms25105309
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
IR-783, a commercially available near-infrared (NIR) heptamethine cyanine dye, has been used for selective tumor imaging in breast, prostate, cervical, and brain cancers in vitro and in vivo. Although the molecular mechanism behind the structure-inherent tumor targeting of IR-783 has not been well-demonstrated, IR-783 has unique properties such as a good water solubility and low cytotoxicity compared with other commercial heptamethine cyanine dyes. The goal of this study is to evaluate the phototherapeutic efficacy of IR-783 as a tumor-targeted photothermal agent in human colorectal cancer xenografts. The results demonstrate that IR-783 shows both the subcellular localization in HT-29 cancer cells and preferential accumulation in HT-29 xenografted tumors 24 h after its intravenous administration. Furthermore, the IR-783 dye reveals the superior capability to convert NIR light into heat energy under 808 nm NIR laser irradiation in vitro and in vivo, thereby inducing cancer cell death. Taken together, these findings suggest that water-soluble anionic IR-783 can be used as a bifunctional phototherapeutic agent for the targeted imaging and photothermal therapy (PTT) of colorectal cancer. Therefore, this work provides a simple and effective approach to develop biocompatible, hydrophilic, and tumor-targetable PTT agents for targeted cancer phototherapy.
引用
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页数:14
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