COVID-19 among lung cancer patients: Data from a real-life prospective French multicentric study

被引：0

作者：

Olivier, Molinier ^{[1
]}

Julian, Pinsolle ^{[2
]}

Acya, Bizieux-Thaminy ^{[3
]}

Sophie, Schneider ^{[4
]}

Benoit, Godbert ^{[5
]}

Laurent, Portel ^{[6
]}

Hugues, Francois ^{[7
]}

Charles, Dayen ^{[8
]}

Julie, Obert ^{[9
]}

Cecile, Dujon ^{[10
,11
]}

Patrick, Dumont ^{[12
]}

Sylvie, Julien ^{[13
]}

Nicolas, Meyer ^{[14
]}

Alexia, Letierce ^{[14
]}

Hugues, Morel ^{[15
]}

Didier, Debieuvre ^{[16
]}

机构：

[1] Ctr Hosp Le Mans, Resp Med Dept, 194Av, F-72037 Le Mans, France

[2] Ctr Hosp Metropole Savoie, Resp Med Dept, Aix les bains, France

[3] Ctr Hosp Dept Vendee, Resp Med Dept, La Roche sur yon, France

[4] Ctr Hosp Cote Basque, Resp Med Dept, Bayonne, France

[5] Cochin Hosp, AP HP, Resp & Intens Care Med Dept, Paris, France

[6] Ctr Hosp Robert Boulin, Libourne, France

[7] Ctr Hosp Polynesie francaise, Resp Med Dept, Papeete, France

[8] Ctr Hosp St Quentin, Resp Med Dept, St Quentin en Yvelines, France

[9] Grp Hosp Intercommunal Raincy Montfermeil, Resp Med Dept, Montfermeil, France

[10] Ctr Hosp Versailles, Resp Med Dept, Versailles, France

[11] Ctr Hosp Chauny, Resp Med Dept, Chauny, France

[12] Ctr Hosp Rodez, Resp Med Dept, Rodez, France

[13] CHU Strasbourg, Publ Hlth Dept, GMRC, Strasbourg, France

[14] QualityStat, Morangis, France

[15] Ctr Hosp Reg Orleans Hop Source, Resp Med Dept, Orleans, France

[16] Hosp Grp Mulhouse Sud Alsace Reg, Emile Muller Hosp, Resp Med Dept, Mulhouse, France

来源：

RESPIRATORY MEDICINE AND RESEARCH | 2024年 / 86卷

关键词：

Lung cancer; Covid; Mortality; Stages; RISK-FACTORS; CLINICAL CHARACTERISTICS; MORTALITY; SEVERITY; DISEASE; IMPACT; CHINA;

D O I：

10.1016/j.resmer.2024.101093

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Background: COVID-19 started to spread early in 2020, the precise year that lung cancer (LC) patients were recruited into the prospective epidemiological cohort KBP-2020-CPHG in French hospitals. This provides a unique opportunity to study COVID-19 incidence, survival risk factors, and overall prognosis. Methods: COVID data was collected before vaccination was made available. Clinical characteristics were compared (COVID vs non-COVID), incidence rate ratios were calculated based on clinical characteristics, survival (1 and 3 months) was estimated and the impact of COVID-19 on the overall prognosis of the cohort was studied. Results: In 2020, 285 out of 8,999 lung cancer patients were diagnosed with COVID-19. Diagnosis was mainly based on PCR tests (86.3 %). The annual incidence was 8.3 % (95 % CI [7.4, 9.3]); it was higher in former smokers and patients with squamous cell carcinoma or small cell carcinoma than in those with adenocarcinoma, in those with a PS score >= 2 versus 0-1, and with stages III-IV versus stages I-II. The incidence was reduced in patients who received chemotherapy or immunotherapy. 64.9 % of patients were hospitalized due to COVID-19. Risk factors for death at 1 and 3 months in COVID-19 patients were age, LC stage, and PS score. Multivariate analysis showed a major prognostic impact of COVID-19 on mortality of LC patients (hazard ratio: 4.12, 95 % CI [3.42, 4.97], p < 0.001). Conclusions: This prospective study demonstrated the high incidence of COVID-19 in LC patients and identified as risk factors for COVID-19: smoking status, histology, PS, and stage. The impact of COVID-19 on lung cancer mortality appears major.

引用

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