Stem Cell-Derived Extracellular Vesicles: Promising Therapeutic Opportunities for Diabetic Wound Healing

被引：5
作者：
Zhang, Boyu [1 ]
Bi, Yajun [2 ]
Wang, Kang [1 ]
Guo, Xingjun [3 ]
Liu, Zeming [1 ]
Li, Jia [1 ,4 ]
Wu, Min [1 ,4 ]
机构：
[1] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Plast & Cosmet Surg, Wuhan 430030, Peoples R China
[2] Dalian Med Univ, Dalian Municipal Women & Childrens Med Ctr Grp, Dept Pediat, Dalian 116011, Liaoning, Peoples R China
[3] Huazhong Univ Sci & Technol, Affiliated Tongji Hosp, Tongji Med Coll, Dept Biliary Pancreat Surg, Wuhan 430030, Hubei, Peoples R China
[4] Tongji Med Coll, Dept Plast & Cosmet Surg, Tongji Hosp, 1095 Jiefang Ave, Wuhan, Hubei, Peoples R China
来源：
INTERNATIONAL JOURNAL OF NANOMEDICINE | 2024年 / 19卷
基金：
中国国家自然科学基金;
关键词：
diabetes; wound healing; stem cells; EVs; ncRNAs; regeneration; ENDOTHELIAL PROGENITOR CELLS; PROMOTING ANGIOGENESIS; CANCER PROGRESSION; FOOT ULCERS; EXOSOMES; REPAIR; PROLIFERATION; PERSPECTIVE; EXPRESSION; STRATEGY;
D O I：
10.2147/IJN.S461342
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
Wound healing is a sophisticated and orderly process of cellular interactions in which the body restores tissue architecture and functionality following injury. Healing of chronic diabetic wounds is difficult due to impaired blood circulation, a reduced immune response, and disrupted cellular repair mechanisms, which are often associated with diabetes. Stem cell-derived extracellular vesicles (SC-EVs) hold the regenerative potential, encapsulating a diverse cargo of proteins, RNAs, and cytokines, presenting a safe, bioactivity, and less ethical issues than other treatments. SC-EVs orchestrate multiple regenerative processes by modulating cellular communication, increasing angiogenesis, and promoting the recruitment and differentiation of progenitor cells, thereby potentiating the reparative milieu for diabetic wound healing. Therefore, this review investigated the effects and mechanisms of EVs from various stem cells in diabetic wound healing, as well as their limitations and challenges. Continued exploration of SC-EVs has the potential to revolutionize diabetic wound care.
引用
收藏
页码：4357 / 4375
页数：19
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