Prevalence of cardiovascular drug-related adverse drug reactions consultations in UK primary care: A cross-sectional study

被引:1
作者
Insani, Widya N. [1 ,2 ,3 ]
Whittlesea, Cate [2 ]
Wei, Li [2 ,4 ]
机构
[1] Padjadjaran State Univ, Dept Pharmacol & Clin Pharm, Bandung, Indonesia
[2] UCL, Sch Pharm, Res Dept Practice & Policy, London, England
[3] Padjadjaran State Univ, Ctr Excellence Pharmaceut Care Innovat, Bandung, Indonesia
[4] Univ Coll London Hosp NHS Fdn Trust, Ctr Med Optimisat Res & Educ, London, England
关键词
ANGIOTENSIN RECEPTOR BLOCKERS; CONVERTING ENZYME-INHIBITORS; HOSPITAL ADMISSIONS; RETROSPECTIVE COHORT; STATIN INTOLERANCE; BETA-BLOCKERS; RISK-FACTORS; DISEASE; EVENTS; SAFETY;
D O I
10.1371/journal.pone.0307237
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Background Adverse drug reactions (ADRs) represent a significant barrier to achieve optimal treatment outcomes. Cardiovascular drugs, including antihypertensive drugs, lipid-lowering drugs, and antithrombotic drugs, are among the most prescribed medications in the primary care setting.Objectives To estimate the prevalence of cardiovascular drug-related ADRs consultations in United Kingdom (UK) primary care and identify risk factors of these ADRs.Methods This was a cross-sectional study of cardiovascular drug users between 2000-2019 using UK IQVIA Medical Research Data. ADRs consultations were identified using database screening method employing standardised designated codes. The overall and annual age-standardised prevalence was estimated using direct standardisation method using 2019 mid-year UK population. Risk factors of ADRs consultations were estimated using logistic regression model stratified by therapeutic areas.Results The standardised prevalence of consultations related to cardiovascular drugs ADRs was 10.60 (95% CI. 10.46, 10.75) per 1000 patients. Patients aged 70-79 years had the highest occurrence of ADRs consultations. The most frequently drug classes implicated in the ADRs consultations were statins (n = 9,993 events, 27.09%), beta-blockers (n = 8,538 events, 23.15%), ACEIs/ARBs (n = 8,345 events, 22.62%), and aspirin (n = 6,482 events, 17.57%). Risk factors of ADRs consultations were previous history of cardiovascular diseases, e.g., myocardial infarction and stroke; advanced age, comorbidities; diabetes and dyslipidaemia; and polypharmacy.Conclusions The burden of cardiovascular drug-related ADRs consultations in primary care was considerable. Statins, beta-blockers, ACEIs/ARBs, and aspirin were the most frequently implicated drug classes. Closer clinical monitoring should be performed for patients affected by the ADRs to mitigate the risk of suboptimal treatment outcomes.
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