Still Far to Go With Characterisation of Molecular and Genetic Features of Diffuse Large B-Cell Lymphoma in People Living With HIV: A Scoping Review

被引：1

作者：

Manyau, Maudy C. P. ^{[1
,2
]}

Zambuko, Blessing ^{[3
]}

Chatambudza, Moses ^{[1
]}

Zhou, Danai T. ^{[1
,2
]}

Manasa, Justen ^{[1
,2
]}

机构：

[1] Univ Zimbabwe, Dept Lab Diagnost & Invest Sci, Harare, Zimbabwe

[2] Biomed Res & Training Inst, Harare, Zimbabwe

[3] Lancet Labs, Pathol, Harare, Zimbabwe

来源：

ONCOLOGY REVIEWS | 2024年 / 18卷

基金：

美国国家卫生研究院;

关键词：

non-Hodgkin lymphoma; HIV/AIDS; molecular pathology histogenesis; CD10; BCL6; cyclin H; MUM1; CD138; HUMAN-IMMUNODEFICIENCY-VIRUS; AIDS-RELATED LYMPHOMAS; ACTIVE ANTIRETROVIRAL THERAPY; EXPRESSION PROFILE; IMMUNE ACTIVATION; OF-ORIGIN; CLASSIFICATION; SURVIVAL; MARKERS; MUTATIONS;

D O I：

10.3389/or.2024.1375291

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Diffuse large B-cell lymphoma (DLBCL) accounts for half of non-Hodgkin lymphoma cases in people living with human immunodeficiency syndrome (PLWH). The interplay of viremia, immune dysregulation and co-infection with oncogenic viruses play a role in pathogenesis of DLBCL in PLWH (HIV-DLBCL). This scoping review aimed to describe the molecular landscape of HIV-DLBCL, investigate the impact of biomarker on clinical outcomes and describe technologies used to characterise HIV-DLBCL. Thirty-two papers published between 2001 and 2023 were included in this review. Samples of HIV-DLBCL were relatively small (16-110). Cohort effects influenced frequencies of molecular characteristics hence their impact on survival was not clear. Molecular features were distinct from HIV-unrelated DLBCL. The most frequently assessed characteristic was cell of origin (81.3% of studies). Somatic mutations were the least researched (6.3% of studies). Overall, biomarker identification in HIV-DLBCL requires broader richer data from larger or pooled samples using more powerful techniques such as next-generation sequencing.

引用

页数：10

共 55 条

[1] Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling [J].

Alizadeh, AA ;

Eisen, MB ;

Davis, RE ;

Ma, C ;

Lossos, IS ;

Rosenwald, A ;

Boldrick, JG ;

Sabet, H ;

Tran, T ;

Yu, X ;

Powell, JI ;

Yang, LM ;

Marti, GE ;

Moore, T ;

Hudson, J ;

Lu, LS ;

Lewis, DB ;

Tibshirani, R ;

Sherlock, G ;

Chan, WC ;

Greiner, TC ;

Weisenburger, DD ;

Armitage, JO ;

Warnke, R ;

Levy, R ;

Wilson, W ;

Grever, MR ;

Byrd, JC ;

Botstein, D ;

Brown, PO ;

Staudt, LM .

NATURE, 2000, 403 (6769) :503-511

[2] A new prognostic score for AIDS-related lymphomas in the rituximab-era [J].

Barta, Stefan K. ;

Xue, Xiaonan ;

Wang, Dan ;

Lee, Jeannette Y. ;

Kaplan, Lawrence D. ;

Ribera, Josep-Maria ;

Oriol, Albert ;

Spina, Michele ;

Tirelli, Umberto ;

Boue, Francois ;

Wilson, Wyndham H. ;

Wyen, Christoph ;

Dunleavy, Kieron ;

Noy, Ariela ;

Sparano, Joseph A. .

HAEMATOLOGICA, 2014, 99 (11) :1731-1737

[3] Outcomes for HIV-associated diffuse large B-cell lymphoma in the modern combined antiretroviral therapy era [J].

Besson, Caroline ;

Lancar, Remi ;

Prevot, Sophie ;

Algarte-Genin, Michele ;

Delobel, Pierre ;

Bonnet, Fabrice ;

Meyohas, Marie-Caroline ;

Partisani, Marialuisa ;

Oberic, Lucie ;

Gabarre, Jean ;

Goujard, Cecile ;

Boue, Francois ;

Coppo, Paul ;

Costello, Regis ;

Hendel-Chavez, Houria ;

Mekerri, Nawel ;

Dos Santos, Gabriella ;

Recher, Christian ;

Delarue, Richard ;

Casasnovas, Rene-Olivier ;

Taoufik, Yassine ;

Mounier, Nicolas ;

Costagliola, Dominique .

AIDS, 2017, 31 (18) :2493-2501

[4] B-Cell Stimulatory Cytokines and Markers of Immune Activation Are Elevated Several Years Prior to the Diagnosis of Systemic AIDS-Associated Non-Hodgkin B-Cell Lymphoma [J].

Breen, Elizabeth Crabb ;

Hussain, Shehnaz K. ;

Magpantay, Larry ;

Jacobson, Lisa P. ;

Detels, Roger ;

Rabkin, Charles S. ;

Kaslow, Richard A. ;

Variakojis, Daina ;

Bream, Jay H. ;

Rinaldo, Charles R. ;

Ambinder, Richard F. ;

Martinez-Maza, Otoniel .

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2011, 20 (07) :1303-1314

[5] Mutations of CD79A, CD79B and EZH2 genes in immunodeficiency-related non-Hodgkin lymphomas [J].

Capello, Daniela ;

Gloghini, Annunziata ;

Martini, Maurizio ;

Spina, Michele ;

Tirelli, Umberto ;

Bertoni, Francesco ;

Rinaldi, Andrea ;

Morra, Enrica ;

Rambaldi, Alessandro ;

Sinigaglia, Fabiola ;

Larocca, Luigi Maria ;

Carbone, Antonino .

BRITISH JOURNAL OF HAEMATOLOGY, 2011, 152 (06) :777-780

[6] Genome wide DNA-profiling of HIV-related B-cell lymphomas [J].

Capello, Daniela ;

Scandurra, Marta ;

Poretti, Giulia ;

Rancoita, Paola M. V. ;

Mian, Michael ;

Gloghini, Annunziata ;

Deambrogi, Clara ;

Martini, Maurizio ;

Rossi, Davide ;

Greiner, Timothy C. ;

Chan, Wing C. ;

Ponzoni, Maurilio ;

Moreno, Santiago M. ;

Piris, Miguel A. ;

Canzonieri, Vincenzo ;

Spina, Michele ;

Tirelli, Umberto ;

Inghirami, Giorgio ;

Rinaldi, Andrea ;

Zucca, Emanuele ;

Favera, Riccardo D. ;

Cavalli, Franco ;

Larocca, Luigi Maria ;

Kwee, Ivo ;

Carbone, Antonino ;

Gaidano, Gianluca ;

Bertoni, Francesco .

BRITISH JOURNAL OF HAEMATOLOGY, 2010, 148 (02) :245-255

[7] Expression profile of MUM1/IRF4, BCL-6, and CD138/syndecan-1 defines novel histogenetic subsets of human immunodeficiency virus-related lymphomas [J].

Carbone, A ;

Gloghini, A ;

Larocca, LM ;

Capello, D ;

Pierconti, F ;

Canzonieri, V ;

Tirelli, U ;

Dalla-Favera, R ;

Gaidano, G .

BLOOD, 2001, 97 (03) :744-751

[8] Diffuse large B-cell lymphoma in a South African cohort with a high HIV prevalence: an analysis by cell-of-origin, Epstein-Barr virus infection and survival [J].

Cassim, Sumaiya ;

Antel, Katherine ;

Chetty, Dharshnee Rama ;

Oosthuizen, Jenna ;

Opie, Jessica ;

Mohamed, Zainab ;

Verburgh, Estelle .

PATHOLOGY, 2020, 52 (04) :453-459

[9] Immunophenotypic Analysis of AIDS-Related Diffuse Large B-Cell Lymphoma and Clinical Implications in Patients From AIDS Malignancies Consortium Clinical Trials 010 and 034 [J].

Chadburn, Amy ;

Chiu, April ;

Lee, Jeannette Y. ;

Chen, Xia ;

Hyjek, Elizabeth ;

Banham, Alison H. ;

Noy, Ariela ;

Kaplan, Lawrence D. ;

Sparano, Joseph A. ;

Bhatia, Kishor ;

Cesarman, Ethel .

JOURNAL OF CLINICAL ONCOLOGY, 2009, 27 (30) :5039-5048

[10] Novel tumor markers provide improved prediction of survival after diagnosis of human immunodeficiency virus (HIV)-related diffuse large B-cell lymphoma [J].

Chao, Chun ;

Silverberg, Michael J. ;

Chen, Lie-Hong ;

Xu, Lanfang ;

Martinez-Maza, Otoniel ;

Abrams, Donald I. ;

Zha, Hongbin D. ;

Haque, Reina ;

Said, Jonathan .

LEUKEMIA & LYMPHOMA, 2018, 59 (02) :321-329

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