Etoposide-based treatment of adult HLH is associated with high biochemical response but poor survival outcomes

被引：7
作者：
Nicholson, Matthew C. [1 ]
Naeije, Leonie [2 ]
Hayden, Anna R. [1 ]
Mattman, Andre [3 ]
Dix, David [2 ]
Chen, Luke Y. C. [1 ,4 ]
机构：
[1] Univ British Columbia, Dept Med, Div Hematol, 2775 Laurel St,10th Floor, Vancouver, BC V5Z 1M9, Canada
[2] Univ British Columbia, Dept Paediat, Div Hematol Oncol & Bone Marrow Transplant, Vancouver, BC, Canada
[3] Univ British Columbia, Dept Pathol & Lab Med, Vancouver, BC, Canada
[4] Univ British Columbia, Ctr Hlth Educ Scholarship, Vancouver, BC, Canada
来源：
EJHAEM | 2020年 / 1卷 / 01期
关键词：
etoposide; ferritin; hemophagocytic; HLH; soluble interleukin-2 receptor; HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS;
D O I：
10.1002/jha2.57
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Etoposide-based treatment is the standard of care for adult HLH in many centers, yet there remains a paucity of data regarding treatment outcomes. We conducted a retrospective study of 23 adults treated with etoposide-based therapy compared to 10 pediatric HLH cases at a single center. At diagnosis, the median serum ferritin was 20,071 mu g/L and 937 mu g/L in adults and children, respectively; median sIL-2r was 14,524 U/mL and 4,478 U/mL. Biochemical response to treatment was high, with 21/23 adults achieving >75% reduction in serum ferritin, but one year survival was only 7/21 compared to 7/10 in pediatric cases.
引用
收藏
页码：277 / 280
页数：4
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