Dapagliflozin ameliorates myocardial infarction injury through AMPKα-dependent regulation of oxidative stress and apoptosis

被引:3
作者
Peng, Yuce [1 ,3 ]
Guo, Mingyu [1 ,3 ]
Luo, Minghao [1 ,3 ]
Lv, Dingyi [1 ,3 ]
Liao, Ke [1 ,3 ]
Luo, Suxin [1 ,3 ]
Zhang, Bingyu [1 ,2 ]
机构
[1] Chongqing Med Univ, Affiliated Hosp 1, Dept Cardiol, Chongqing 400016, Peoples R China
[2] East China Normal Univ, Wuhu Hosp, Dept Cardiol, Wuhu, Peoples R China
[3] Chongqing Med Univ, Cardiovasc Dis Lab, Chongqing 400016, Peoples R China
基金
中国国家自然科学基金;
关键词
Myocardial infarction; Dapagliflozin; Oxidative stress; AMPK alpha; Apoptosis; ISCHEMIC-HEART; EMPAGLIFLOZIN; INFLAMMASOME; INHIBITION; REDUCTION; OUTCOMES; SGLT2;
D O I
10.1016/j.heliyon.2024.e29160
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Dapagliflozin (DAPA) has been demonstrated to reduce cardiovascular mortality and heart failure hospitalization rates in diabetic patients. However, the mechanism underlying its cardioprotective effect in non-diabetic patients remains unclear. Our study aimed to explore the cardio-protective impact of DAPA on myocardial infarction in non-diabetic mice. We induced myocardial infarction in C57BL/6 mice by ligating the descending branch of the left coronary artery. After surgery, the animals were randomly treated with either saline or DAPA. We employed echocardiography, Western blot analysis, and tissue staining to assess post-infarction myocardial injury. Additionally, we investigated the mechanism of action through cell experiments. Compared to the myocardial infarction group, DAPA treatment significantly attenuated ventricular remodeling and improved cardiac function. By mitigating myocardial oxidative stress and apoptosis, DAPA may activate the AMPK alpha signaling pathway, thereby exerting a protective effect. These findings suggest that DAPA could serve as a novel therapeutic approach for patients with cardiac infarction.
引用
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页数:15
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