Induction of protective immune responses at respiratory mucosal sites

被引：13

作者：

Park, Seok-Chan ^{[1
,2
]}

Wiest, Matthew J. ^{[3
,4
]}

Yan, Vivian ^{[1
,2
,5
]}

Wong, Pamela T. ^{[3
,4
,6
]}

Schotsaert, Michael ^{[1
,2
,7
,8
]}

机构：

[1] Icahn Sch Med Mt Sinai, Dept Microbiol, New York, NY 10029 USA

[2] Icahn Sch Med Mt Sinai, Global Hlth & Emerging Pathogens Inst, New York, NY 10029 USA

[3] Univ Michigan, Med Sch, Dept Internal Med, Ann Arbor, MI USA

[4] Univ Michigan, Michigan Nanotechnol Inst Med & Biol Sci, Med Sch, Ann Arbor, MI USA

[5] Icahn Sch Med Mt Sinai, Grad Sch Biomed Sci, New York, NY 10029 USA

[6] Univ Michigan, Mary H Weiser Food Allergy Ctr, Med Sch, Ann Arbor, MI USA

[7] Icahn Sch Med Mt Sinai, Icahn Genom Inst, New York, NY 10029 USA

[8] Icahn Sch Med Mt Sinai, Marc & Jennifer Lipschultz Precis Immunol Inst, New York, NY 10029 USA

来源：

HUMAN VACCINES & IMMUNOTHERAPEUTICS | 2024年 / 20卷 / 01期

基金：

美国国家卫生研究院;

关键词：

Mucosal; respiratory tract; vaccine; adjuvant; virus; vaccinology; INFLUENZA VACCINES; RECENT PROGRESS; CUTTING EDGE; ADJUVANT; MEMORY; INFECTION; CELLS; VACCINATION; SYSTEM; NANOPARTICLES;

D O I：

10.1080/21645515.2024.2368288

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Many pathogens enter the host through mucosal sites. Thus, interfering with pathogen entry through local neutralization at mucosal sites therefore is an effective strategy for preventing disease. Mucosally administered vaccines have the potential to induce protective immune responses at mucosal sites. This manuscript delves into some of the latest developments in mucosal vaccination, particularly focusing on advancements in adjuvant technologies and the role of these adjuvants in enhancing vaccine efficacy against respiratory pathogens. It highlights the anatomical and immunological complexities of the respiratory mucosal immune system, emphasizing the significance of mucosal secretory IgA and tissue-resident memory T cells in local immune responses. We further discuss the differences between immune responses induced through traditional parenteral vaccination approaches vs. mucosal administration strategies, and explore the protective advantages offered by immunization through mucosal routes.

引用

页数：12

共 109 条

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