Three-Way Translocation t(12;15;17) (p13;q24;q21) Found in Acute Promyelocytic Leukemia with Basophilic Differentiation

被引：0
|
作者：
Frazzetto, Sara [1 ,2 ]
Gullo, Lara [1 ,2 ]
Sapuppo, Gabriele [1 ,2 ]
Fazio, Manlio [1 ,2 ]
Lo Faro, Cristina [1 ,2 ]
Giunta, Giuliana [1 ,2 ]
Caravotta, Ignazio [1 ,2 ]
Mauro, Elisa [1 ]
Parisi, Marina Silvia [1 ]
Triolo, Anna Maria [1 ]
Parrinello, Nunziatina Laura [1 ]
Consoli, Maria Letizia [1 ]
Tambe, Loredana [1 ]
Cambria, Daniela [1 ]
Marino, Sara [1 ]
Scuderi, Grazia [1 ]
Di Raimondo, Francesco [1 ,2 ]
机构：
[1] Azienda Policlin San Marco, Div Hematol, I-95123 Catania, Italy
[2] Univ Catania, Postgrad Sch Hematol, Catania, Italy
来源：
HEMATOLOGY REPORTS | 2024年 / 16卷 / 02期
关键词：
acute myeloid leukemia; acute promyelocytic leukemia; basophils; cytogenetic; translocation; treatment; BREAKPOINT; REGION;
D O I：
10.3390/hematolrep16020037
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Acute promyelocytic leukemia is a rare form of acute myeloid leukemia in which immature promyelocytes abnormally proliferate in the bone marrow. In most cases, the disease is characterised by the translocation t(15;17) (q24;q21), which causes the formation of PML::RARA, an oncogenic fusion protein responsible for blocking myeloid differentiation and survival advantage. Here, we present a case of acute promyelocytic leukemia with two unusual features: basophilic differentiation and a three-way translocation involving chromosomes 12, 15 and 17. In the few cases reported, basophilic differentiation was associated with a poor prognosis. In contrast, our patient responded promptly to the standard treatment with all-trans-retinoic acid (ATRA) and arsenic trioxide (ATO) and obtained complete remission. To our knowledge, this is the first report of basophilic acute promyelocytic leukemia with the three-way translocation t(12;17;15) (p13; q24;q21).
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页码：367 / 374
页数：8
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