Multifunctional pH-responsive hydrogel dressings based on carboxymethyl chitosan: Synthesis, characterization fostering the wound healing

被引:21
|
作者
Xiong, Mingxin [1 ]
Chen, Yu [1 ]
Hu, Han-Jian [1 ]
Cheng, Hao [1 ]
Li, Wei-Xiong [1 ]
Tang, Shipeng [1 ]
Hu, Xiaolong [1 ]
Lan, Ling -Min [1 ]
Zhang, Hongyan [1 ,2 ]
Jiang, Gang-Biao [1 ]
机构
[1] South China Agr Univ, Coll Mat & Energy, Key Lab Biobased Mat & Energy, Minist Educ, Guangzhou 510642, Peoples R China
[2] South China Agr Univ, Coll Vet Med, Natl Risk Assessment Lab Antimicrobial Resistance, Guangzhou 510642, Peoples R China
关键词
pH-responsive; Carboxymethyl chitosan; Tannic acid; Hydrogel dressing; Anti-bacterial; Self-adaptive; NETWORKS; IMPROVE; POLYMER;
D O I
10.1016/j.carbpol.2024.122348
中图分类号
O69 [应用化学];
学科分类号
081704 ;
摘要
Antibiotic abuse is increasing the present rate of drug -resistant bacterial wound infections, producing a significant healthcare burden globally. Herein, we prepared a pH -responsive CMCS/PVP/TA (CPT) multifunctional hydrogel dressing by embedding the natural plant extract TA as a nonantibiotic and cross -linking agent in carboxymethyl chitosan (CMCS) and polyvinylpyrrolidone (PVP) to prompt wound healing. The CPT hydrogel demonstrated excellent self -healing, self -adaptive, and adhesion properties to match different wound requirements. Importantly, this hydrogel showed pH sensitivity and exhibited good activity against resistant bacteria and antioxidant activity by releasing TA in case of bacterial infection (alkaline). Furthermore, the CPT hydrogel exhibited coagulant ability and could rapidly stop bleeding within 30 s. The biocompatible hydrogel effectively accelerated wound healing in a full -thickness skin defect model by thickening granulation tissue, increasing collagen deposition, vascular proliferation, and M2 -type macrophage polarization. In conclusion, this study demonstrates that multifunctional CPT hydrogel offers a candidate material with potential applications for infected skin wound healing.
引用
收藏
页数:14
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