Formulation and Characterization of a Novel Oxidized Alginate-Gelatin-Silk Fibroin Bioink with the Aim of Skin Regeneration

被引：0
|
作者：
Sanaei, Khadijeh [1 ]
Zamanian, Ali [1 ]
Mashayekhan, Shohreh [2 ]
Ramezani, Tayebe [3 ]
机构：
[1] Mat & Energy Res Ctr, Dept Nanotechnol & Adv Mat, Karaj, Iran
[2] Sharif Univ Technol, Dept Chem & Petr Engn, Tehran, Iran
[3] Kharazmi Univ, Fac Biol Sci, Tehran, Iran
来源：
IRANIAN BIOMEDICAL JOURNAL | 2023年 / 27卷 / 05期
关键词：
Alginate; Bioprinting; Fibroin; Gelatin;
D O I：
10.52547/ibj.3981
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Background: In the present study, a novel bioink was suggested based on the OAlg, GL, and SF hydrogels.Methods: The composition of the bioink was optimized by the rheological and printability measurements, and the extrusion-based 3D bioprinting process was performed by applying the optimum OAlg-based bioink.Results: The results demonstrated that the viscosity of bioink was continuously decreased by increasing the SF/GL ratio, and the bioink displayed a maximum achievable printability (92 +/- 2%) at 2% (w/v) of SF and 4% (w/v) of GL. Moreover, the cellular behavior of the scaffolds investigated by MTT assay and live/dead staining confirmed the biocompatibility of the prepared bioink.Conclusion: The bioprinted OAlg-GL-SF scaffold could have the potential for using in skin tissue engineering applications, which needs further exploration.
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收藏
页码：280 / 293
页数：14
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