Safety and immunogenicity of a first dose of SARS-CoV-2 mRNA vaccine in allogeneic hematopoietic stem-cells recipients

被引：32

作者：

Chevallier, Patrice ^{[1
,2
,5
]}

Coste-Burel, Marianne ^{[3
]}

Le Bourgeois, Amandine ^{[1
]}

Peterlin, Pierre ^{[1
]}

Garnier, Alice ^{[1
]}

Bene, Marie C. ^{[3
,4
]}

Imbert, Berthe-Marie ^{[2
]}

Drumel, Thomas ^{[3
]}

Le Gouill, Steven ^{[1
]}

Moreau, Philippe ^{[1
]}

Mahe, Beatrice ^{[1
]}

Dubruille, Viviane ^{[1
]}

Blin, Nicolas ^{[1
]}

Lok, Anne ^{[1
]}

Touzeau, Cyrille ^{[1
]}

Gastinne, Thomas ^{[1
]}

Jullien, Maxime ^{[1
]}

Vanthygem, Sophie ^{[1
]}

Guillaume, Thierry ^{[1
,2
]}

机构：

[1] Nantes Univ Hosp, Dept Hematol, Nantes, France

[2] Univ Nantes, INSERM UMR1232, CRCINA IRS UN, Nantes, France

[3] Nantes Univ Hosp, Dept Virol, Nantes, France

[4] Nantes Univ Hosp, Dept Hematol Biol, Nantes, France

[5] CHU Hotel Dieu, Serv Hematol Clin, Pl A Ricordeau, F-44093 Nantes, France

来源：

EJHAEM | 2021年 / 2卷 / 03期

关键词：

RISK-FACTORS; MULTICENTER; COVID-19;

D O I：

10.1002/jha2.242

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This was a monocentric prospective study testing the efficacy and safety of a first injection of BNT162b2 (Pfizer-BioNTech) in 112 Allo-HSCT patients. Antibody response to SARS-CoV-2 spike protein receptor-binding domain was tested at the time of the second injection (Roche Elecsys). The study also included a non-randomized control arm of 26 healthy controls. This study shows that a first dose of SARS-CoV-2 messenger RNA vaccine is safe and provides a 55% rate of seroconversion in allotransplanted patients compared to 100% for the controls (p < 0.001). Factors influencing the absence of response in patients were recent transplantation (<2 years), lymphopenia (<1 x 10(9)/L) and immunosuppressive treatment or chemotherapy at the time of vaccination.

引用

页码：520 / 524

页数：5

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