Supramolecular Hydrogel Inspired from DNA Structures Mimics Peroxidase Activity

被引：51

作者：

Bhattacharyya, Tanima ^{[1
]}

Kumar, Y. Pavan ^{[1
]}

Dash, Jyotirmayee ^{[1
]}

机构：

[1] Indian Assoc Cultivat Sci, Dept Organ Chem, Kolkata 700032, India

来源：

ACS BIOMATERIALS SCIENCE & ENGINEERING | 2017年 / 3卷 / 10期

关键词：

DNAzyme; enzyme mimic; guanosine; logic operation; supramolecular chemistry; G-QUADRUPLEX STRUCTURES; LOGIC-GATE OPERATIONS; C-DI-GMP; ION CHANNELS; G(4)CENTER-DOT-K+ HYDROGEL; COLORIMETRIC DETECTION; GUANOSINE DERIVATIVES; CONTROLLED-RELEASE; G-QUARTET; ACID;

D O I：

10.1021/acsbiomaterials.7b00563

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

We herein report that hydrogels can be prepared from guanosine and boronic acids in the presence of K+ and Pb2+ ions. These supramolecular hydrogels are formed via G-quartet like self-assembly of guanosine and its boronate esters. The potential of this hydrogel construct in mimicking enzyme-like activity has been demonstrated for the first time. We have observed that the self assembled structure present in K+ stabilized hydrogel binds to iron(III)-hemin and shows peroxidase activity, catalyzing oxidation of 3,3',5,5'-tetramethylbenzidine (TMB) in the presence of H2O2. Furthermore, the conformation of the G-quartet assemblies in the hydrogel can be altered by varying the stabilizing cations K+ and Pb2+. This conformational switching has been used to devise a molecular logic gate for sensing of toxic Pb2+ ions.

引用

页码：2358 / 2365

页数：8

共 79 条

[1] Nucleobase-containing gelators [J].

Araki, K ;

Yoshikawa, I .

LOW MOLECULAR MASS GELATORS: DESIGN, SELF-ASSEMBLY, FUNCTION, 2005, 256 :133-165

[2] Functional π-Gelators and Their Applications [J].

Babu, Sukumaran Santhosh ;

Praveen, Vakayil K. ;

Ajayaghosh, Ayyappanpillai .

CHEMICAL REVIEWS, 2014, 114 (04) :1973-2129

[3]

Bang I, 1910, BIOCHEM Z, V26, P293

[4] Toward potential supramolecular tissue engineering scaffolds based on guanosine derivatives [J].

Buerkle, Lauren E. ;

von Recum, Horst A. ;

Rowan, Stuart J. .

CHEMICAL SCIENCE, 2012, 3 (02) :564-572

[5] Tailoring the Properties of Guanosine-Based Supramolecular Hydrogels [J].

Buerkle, Lauren E. ;

Li, Zheng ;

Jamieson, Alexander M. ;

Rowan, Stuart J. .

LANGMUIR, 2009, 25 (15) :8833-8840

[6] 5′-UTR RNA G-quadruplexes: translation regulation and targeting [J].

Bugaut, Anthony ;

Balasubramanian, Shankar .

NUCLEIC ACIDS RESEARCH, 2012, 40 (11) :4727-4741

[7] THE INFRARED SPECTRA OF BIS(ALKYLAMINO) PHENYLBORONS AND DIALKYL PHENYLBORONATES [J].

BURCH, JE ;

GERRARD, W ;

GOLDSTEIN, M ;

MOONEY, EF ;

WILLIS, HA .

SPECTROCHIMICA ACTA, 1962, 18 (11) :1403-1419

[8] Quadruplex DNA: sequence, topology and structure [J].

Burge, Sarah ;

Parkinson, Gary N. ;

Hazel, Pascale ;

Todd, Alan K. ;

Neidle, Stephen .

NUCLEIC ACIDS RESEARCH, 2006, 34 (19) :5402-5415

[9] General Peroxidase Activity of G-Quadruplex-Hemin Complexes and Its Application in Ligand Screening [J].

Cheng, Xiaohong ;

Liu, Xiangjun ;

Bing, Tao ;

Cao, Zehui ;

Shangguan, Dihua .

BIOCHEMISTRY, 2009, 48 (33) :7817-7823

[10] STEADY-STATE KINETICS OF PEROXIDASE WITH 2,2'-AZINO-DI-(3-ETHYLBENZTHIAZOLINE-6-SULPHONIC ACID) AS CHROMOGEN [J].

CHILDS, RE ;

BARDSLEY, WG .

BIOCHEMICAL JOURNAL, 1975, 145 (01) :93-103

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