Multi-omics Analysis Reveals Key Gut Microbiota and Metabolites Closely Associated with Huntington's Disease

被引:1
作者
Qian, Shu-Xia [1 ,2 ,3 ]
Bao, Yu-Feng [1 ]
Li, Xiao-Yan [1 ]
Dong, Yi [1 ]
Zhang, Xiao-Ling [3 ]
Wu, Zhi-Ying [1 ,2 ]
机构
[1] Zhejiang Univ, Dept Med Genet, Sch Med, 88 Jiefang Rd, Hangzhou, Zhejiang, Peoples R China
[2] Nanhu Brain Comp Interface Inst, Hangzhou, Peoples R China
[3] Jiaxing Univ, Affiliated Hosp 2, Dept Neurol, 1518 Huancheng North Rd, Jiaxing, Zhejiang, Peoples R China
关键词
Huntington's disease; Multi-omics analysis; Gut microbiota; Association;
D O I
10.1007/s12035-024-04271-9
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Dysbiosis of the gut microbiota is closely associated with neurodegenerative diseases, including Huntington's disease (HD). Gut microbiome-derived metabolites are key factors in host-microbiome interactions. This study aimed to investigate the crucial gut microbiome and metabolites in HD and their correlations. Fecal and serum samples from 11 to 26 patients with HD, respectively, and 16 and 23 healthy controls, respectively, were collected. The fecal samples were used for shotgun metagenomics while the serum samples for metabolomics analysis. Integrated analysis of the metagenomics and metabolomics data was also conducted. Firmicutes, Bacteroidota, Proteobacteria, Uroviricota, Actinobacteria, and Verrucomicrobia were the dominant phyla. At the genus level, the presence of Bacteroides, Faecalibacterium, Parabacteroides, Alistipes, Dialister, and Christensenella was higher in HD patients, while the abundance of Lachnospira, Roseburia, Clostridium, Ruminococcus, Blautia, Butyricicoccus, Agathobaculum, Phocaeicola, Coprococcus, and Fusicatenibacter decreased. A total of 244 differential metabolites were identified and found to be enriched in the glycerophospholipid, nucleotide, biotin, galactose, and alpha-linolenic acid metabolic pathways. The AUC value from the integrated analysis (1) was higher than that from the analysis of the gut microbiota (0.8632). No significant differences were found in the ACE, Simpson, Shannon, Sobs, and Chao indexes between HD patients and controls. Our study determined crucial functional gut microbiota and potential biomarkers associated with HD pathogenesis, providing new insights into the role of the gut microbiota-brain axis in HD occurrence and development.
引用
收藏
页码:351 / 365
页数:15
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