Unlocking the biochemical secrets of longevity: balancing healthspan and lifespan

被引：3

作者：

Vina, Jose ^{[1
]}

Borras, Consuelo ^{[1
]}

机构：

[1] Univ Valencia, Inst Hlth Res INCLIVA, Inst Salud Carlos III CIBERFES ISCIII, Freshage Res Grp,Dept Physiol,Fac Med,Ctr Invest B, Valencia, Spain

来源：

FEBS LETTERS | 2024年 / 598卷 / 17期

基金：

欧盟地平线“2020”;

关键词：

healthspan; healthy aging intervention; lifespan; mitochondria; triage theory; ALL-CAUSE MORTALITY; CARDIOVASCULAR-DISEASE; CALORIC RESTRICTION; DIETARY RESTRICTION; BODY-MASS; MITOCHONDRIAL; INTERVENTION; ANTIOXIDANTS; SUPPLEMENTS; BIOGENESIS;

D O I：

10.1002/1873-3468.14963

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In an era of rising global life expectancies, research focuses on enhancing the quality of extended years. This review examines the link between mitochondrial function and aging, highlighting the importance of healthspan alongside lifespan. This involves significant human and economic challenges, with longer lifespans often accompanied by reduced well-being. Addressing mitochondrial decline, exploring targeted interventions, and understanding the complexities of research models are vital for advancing our knowledge in this field. Additionally, promoting physical exercise and adopting personalized supplementation strategies based on individual needs can contribute to healthy aging. The insights from this Perspective article offer a hopeful outlook for future advances in extending both lifespan and healthspan, aiming to improve the overall quality of life in aging populations. In an era of rising global life expectancies, research focuses on enhancing the quality of extended years. Addressing mitochondrial decline, exploring targeted interventions, and understanding the complexities of research models are vital for advancing our knowledge in healthspan. The insights from this Perspective article offer an outlook for future advances in improving the overall quality of life in aging populations. image

引用

页码：2135 / 2144

页数：10