Unlocking the biochemical secrets of longevity: balancing healthspan and lifespan

被引:3
作者
Vina, Jose [1 ]
Borras, Consuelo [1 ]
机构
[1] Univ Valencia, Inst Hlth Res INCLIVA, Inst Salud Carlos III CIBERFES ISCIII, Freshage Res Grp,Dept Physiol,Fac Med,Ctr Invest B, Valencia, Spain
基金
欧盟地平线“2020”;
关键词
healthspan; healthy aging intervention; lifespan; mitochondria; triage theory; ALL-CAUSE MORTALITY; CARDIOVASCULAR-DISEASE; CALORIC RESTRICTION; DIETARY RESTRICTION; BODY-MASS; MITOCHONDRIAL; INTERVENTION; ANTIOXIDANTS; SUPPLEMENTS; BIOGENESIS;
D O I
10.1002/1873-3468.14963
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
In an era of rising global life expectancies, research focuses on enhancing the quality of extended years. This review examines the link between mitochondrial function and aging, highlighting the importance of healthspan alongside lifespan. This involves significant human and economic challenges, with longer lifespans often accompanied by reduced well-being. Addressing mitochondrial decline, exploring targeted interventions, and understanding the complexities of research models are vital for advancing our knowledge in this field. Additionally, promoting physical exercise and adopting personalized supplementation strategies based on individual needs can contribute to healthy aging. The insights from this Perspective article offer a hopeful outlook for future advances in extending both lifespan and healthspan, aiming to improve the overall quality of life in aging populations. In an era of rising global life expectancies, research focuses on enhancing the quality of extended years. Addressing mitochondrial decline, exploring targeted interventions, and understanding the complexities of research models are vital for advancing our knowledge in healthspan. The insights from this Perspective article offer an outlook for future advances in improving the overall quality of life in aging populations. image
引用
收藏
页码:2135 / 2144
页数:10
相关论文
共 50 条
[31]   Healthspan and Longevity in Mammals: A Family Game for Cellular Organelles? [J].
Nisoli, Enzo ;
Valerio, Alessandra .
CURRENT PHARMACEUTICAL DESIGN, 2014, 20 (35) :5663-5670
[32]   HIF-1 modulates longevity and healthspan in a temperature-dependent manner [J].
Leiser, Scott F. ;
Begun, Anisoara ;
Kaeberlein, Matt .
AGING CELL, 2011, 10 (02) :318-326
[34]   Endurance exercise and selective breeding for longevity extend Drosophila healthspan by overlapping mechanisms [J].
Sujkowski, Alyson ;
Bazzell, Brian ;
Carpenter, Kylie ;
Arking, Robert ;
Wessells, Robert J. .
AGING-US, 2015, 7 (08) :535-552
[35]   A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice [J].
Roberts, Megan N. ;
Wallace, Marita A. ;
Tomilov, Alexey A. ;
Zhou, Zeyu ;
Marcotte, George R. ;
Tran, Dianna ;
Perez, Gabriella ;
Gutierrez-Casado, Elena ;
Koike, Shinichiro ;
Knotts, Trina A. ;
Imai, Denise M. ;
Griffey, Stephen M. ;
Kim, Kyoungmi ;
Hagopian, Kevork ;
Haj, Fawaz G. ;
Baar, Keith ;
Cortopassi, Gino A. ;
Ramsey, Jon J. ;
Alberto Lopez-Dominguez, Jose .
CELL METABOLISM, 2017, 26 (03) :539-+
[36]   Longevity interventions temporally scale healthspan in Caenorhabditis elegans [J].
Statzer, Cyril ;
Reichert, Peter ;
Dual, Jurg ;
Ewald, Collin Y. .
ISCIENCE, 2022, 25 (03)
[37]   Lifelong reduction in complex IV induces tissue-specific metabolic effects but does not reduce lifespan or healthspan in mice [J].
Deepa, Sathyaseelan S. ;
Pharaoh, Gavin ;
Kinter, Michael ;
Diaz, Vivian ;
Fok, Wilson C. ;
Riddle, Kaitlyn ;
Pulliam, Daniel ;
Hill, Shauna ;
Fischer, Kathleen E. ;
Soto, Vanessa ;
Georgescu, Constantin ;
Wren, Jonathan D. ;
Viscomi, Carlo ;
Richardson, Arlan ;
Van Remmen, Holly .
AGING CELL, 2018, 17 (04)
[38]   Ginseng volatile oil prolongs the lifespan and healthspan of Caenorhabditis elegans [J].
Wang, Lixin ;
Qiao, Ping ;
Ouyang, Zhuoer ;
Li, Danyang ;
Zheng, Jingtong ;
Wang, Guoqiang ;
Wang, Fang .
BIOGERONTOLOGY, 2022, 23 (04) :485-497
[39]   Collagen peptides from sturgeon swim bladder prolong the lifespan and healthspan in Caenorhabditis elegans [J].
Wang, Lin ;
Li, Peiyu ;
Zheng, Fuping ;
Zhu, Zhiling ;
Bai, Fan ;
Gao, Ruichang .
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, 2024, 104 (09) :5244-5251
[40]   SERCA inhibition improves lifespan and healthspan in a chemical model of Parkinson disease in Caenorhabditis elegans [J].
Romero-Sanz, Silvia ;
Caldero-Escudero, Elena ;
Alvarez-Illera, Pilar ;
Santo-Domingo, Jaime ;
Fonteriz, Rosalba I. I. ;
Montero, Mayte ;
Alvarez, Javier .
FRONTIERS IN PHARMACOLOGY, 2023, 14