In vitro selection of random peptides against artificial lipid bilayers: a potential tool to immobilize molecules on membranes

被引：13

作者：

Kobayashi, Shota ^{[1
]}

Terai, Takuya ^{[1
]}

Yoshikawa, Yuki ^{[1
]}

Ohkawa, Ryoya ^{[1
]}

Ebihara, Mika ^{[1
]}

Hayashi, Masahito ^{[2
]}

Takiguchi, Kingo ^{[2
]}

Nemoto, Naoto ^{[1
]}

机构：

[1] Saitama Univ, Grad Sch Sci & Engn, Sakura Ku, 255 Shimo Okubo, Saitama, Saitama 3388570, Japan

[2] Nagoya Univ, Grad Sch Sci, Div Biol Sci, Chikusa Ku, Furo Cho, Nagoya, Aichi 4648602, Japan

来源：

CHEMICAL COMMUNICATIONS | 2017年 / 53卷 / 24期

关键词：

CELL-PENETRATING PEPTIDES; CATIONIC-HYDROPHOBIC PEPTIDES; ANTIMICROBIAL PEPTIDES; PROTOCELL MEMBRANES; BINDING PEPTIDE; CDNA DISPLAY; PROTEIN; RNA; LIPOSOMES; PUROMYCIN;

D O I：

10.1039/c7cc00099e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The first in vitro selection of binding peptides against artificial lipid membranes from a random peptide library using an in vitro display method (cDNA display) is reported. The selected peptide, LB-1, has both amphiphilic and cationic regions, and proteins fused to LB-1 can be immobilized on the liposome surface.

引用

收藏

页码：3458 / 3461

页数：4

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