Neurotrophin peptidomimetics for the treatment of neurodegenerative diseases

被引：0
|
作者：
Madhubala, Dev [1 ,2 ]
Mahato, Rosy [2 ,3 ]
Khan, Mojibur R. [2 ,3 ]
Bala, Asis [2 ,3 ]
Mukherjee, Ashis K. [1 ,2 ,3 ]
机构：
[1] Tezpur Univ, Dept Mol Biol & Biotechnol, Microbial Biotechnol & Prot Res Lab, Tezpur 784028, Assam, India
[2] Inst Adv Study Sci & Technol, Div Life Sci, Gauhati 781035, Assam, India
[3] Acad Sci & Innovat Res AcSIR, Fac Sci, Ghaziabad 201002, Uttar Pradesh, India
来源：
DRUG DISCOVERY TODAY | 2024年 / 29卷 / 11期
关键词：
neurotrophins; peptidomimetics; neurodegenerative diseases; next-generation drug; NERVE GROWTH-FACTOR; SMALL-MOLECULE; PEPTIDE MIMETICS; P75; RECEPTOR; DESIGN; BDNF; NGF; TRKA; THERAPEUTICS; LIGANDS;
D O I：
10.1016/j.drudis.2024.104156
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Neurotrophins, such as nerve growth factor and brain- derived neurotrophic factor, play an essential role in the survival of neurons. However, incorporating better features can increase their therapeutic efficacy in neurodegenerative diseases (NDs). Peptidomimetics, which mimic these neurotrophins, show potential for treating NDs. This study emphasizes the use of peptidomimetics from neurotrophins for treating NDs and their benefits. By improving bioavailability and stability, these molecules can completely transform the therapy for NDs. This indepth review guides researchers and pharmaceutical developers, providing insight into the changing field of neurodegenerative medicine.
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页数：19
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