Association of body composition indices with cardiovascular outcomes: a nationwide cohort study

被引:3
作者
Kim, Dongyeop [1 ]
Kim, Hyung Jun [2 ]
Song, Tae-Jin [1 ]
机构
[1] Ewha Womans Univ, Seoul Hosp, Coll Med, Dept Neurol, Seoul, South Korea
[2] Sungkyunkwan Univ, Samsung Med Ctr, Sch Med, Dept Neurol, Seoul, South Korea
关键词
body composition; BMI; obesity; fat mass; skeletal muscle mass; cardiovascular outcome; MASS INDEX; PREDICTION EQUATIONS; SARCOPENIC OBESITY; MUSCLE MASS; FAT MASS; HEALTH; VALIDATION; RISK; STROKE; IMPACT;
D O I
10.1016/j.ajcnut.2024.02.015
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Background: Previous studies regarding BMI (kg/m 2 ) and associated cardiovascular outcomes yield inconsistent results. Objectives: We aimed to investigate the association between body composition and cardiovascular outcomes according to BMI categories in the Korean general population. Methods: A total of 2,604,401 participants were enrolled in this nationwide cohort study using the National Health Insurance Service -Health Checkup data set. Predicted lean BMI (pLBMI), body fat mass index (pBFMI), and appendicular skeletal muscle mass index (pASMMI) were calculated using validated anthropometric prediction equations. A multivariable time -dependent Cox regression analysis was conducted to assess the association with cardiovascular outcomes. The results were presented with adjusted hazard ratios (HRs) with 95% con fi dence intervals (CIs), considering BMI categories (BMI < 18.5, BMI 18.5 - 24.9, BMI 25 - 29.9, and BMI >= 30). Results: Higher pLBMI and pASMMI were correlated with a reduced risk of composite cardiovascular outcomes. For pLBMI, HR was 0.910 (95% CI: 0.908, 0.913, P < 0.001) for males and 0.905 (95% CI: 0.899, 0.910, P < 0.001) for females. For pASMMI, HR was 0.825 (95% CI: 0.820, 0.829, P < 0.001) for males and 0.788 (95% CI: 0.777, 0.800, P < 0.001) for females. Conversely, a higher pBFMI was associated with an increased risk, with HR of 1.082 (95% CI: 1.071, 1.093, P < 0.001) for males and 1.181 (95% CI: 1.170, 1.192, P < 0.001) for females. Subgroup analysis based on BMI categories revealed no signi fi cant risk association for pBFMI in the BMI < 18.5 group. In the group with BMI >= 30, neither pLBMI nor pASMMI demonstrated a signi fi cant risk association. Conclusions: Our results highlight the value of pLBMI, pBFMI, and pASMMI as variables for assessing risk of composite cardiovascular outcomes. The signi fi cance of indicators may vary depending on BMI categories.
引用
收藏
页码:876 / 884
页数:9
相关论文
共 50 条
[1]   Derivation and validation of simple equations to predict total muscle mass from simple anthropometric and demographic data [J].
Al-Gindan, Yasmin Y. ;
Hankey, Catherine ;
Govan, Lindsay ;
Gallagher, Dympna ;
Heymsfield, Steven B. ;
Lean, Michael E. J. .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 2014, 100 (04) :1041-1051
[2]   Impact of Obesity and Weight Loss on Cardiac Performance and Morphology in Adults [J].
Alpert, Martin A. ;
Omran, Jad ;
Mehra, Ankit ;
Ardhanari, Sivakumar .
PROGRESS IN CARDIOVASCULAR DISEASES, 2014, 56 (04) :391-400
[3]   Identification of skeletal muscle mass depletion across age and BMI groups in health and disease-there is need for a unified definition [J].
Bosy-Westphal, A. ;
Mueller, M. J. .
INTERNATIONAL JOURNAL OF OBESITY, 2015, 39 (03) :379-386
[4]   Diagnosis of obesity based on body composition-associated health risks-Time for a change in paradigm [J].
Bosy-Westphal, Anja ;
Mueller, Manfred J. .
OBESITY REVIEWS, 2021, 22
[5]   Beyond BMI: The value of more accurate measures of fatness and obesity in social science research [J].
Burkhauser, Richard V. ;
Cawley, John .
JOURNAL OF HEALTH ECONOMICS, 2008, 27 (02) :519-529
[6]   Improved oral hygiene care and chronic kidney disease occurrence A nationwide population-based retrospective cohort study [J].
Chang, Yoonkyung ;
Lee, Ji Sung ;
Woo, Ho Geol ;
Ryu, Dong-Ryeol ;
Kim, Jin-Woo ;
Song, Tae-Jin .
MEDICINE, 2021, 100 (47) :E27845
[7]   Improved oral hygiene is associated with decreased risk of new-onset diabetes: a nationwide population-based cohort study [J].
Chang, Yoonkyung ;
Lee, Ji Sung ;
Lee, Ki-Jung ;
Woo, Ho Geol ;
Song, Tae-Jin .
DIABETOLOGIA, 2020, 63 (05) :924-933
[8]   Improved oral hygiene care is associated with decreased risk of occurrence for atrial fibrillation and heart failure: A nationwide population-based cohort study [J].
Chang, Yoonkyung ;
Woo, Ho Geol ;
Park, Jin ;
Lee, Ji Sung ;
Song, Tae-Jin .
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY, 2020, 27 (17) :1835-1845
[9]  
Chen ZM, 2018, LANCET GLOB HEALTH, V6, pE630, DOI [10.1016/S2214-109X(18)30216-X, 10.1016/s2214-109x(18)30216-x]
[10]   Sarcopenic Obesity Is Significantly Associated With Coronary Artery Calcification [J].
Chung, Goh Eun ;
Park, Hyo Eun ;
Lee, Heesun ;
Kim, Min Joo ;
Choi, Su-Yeon ;
Yim, Jeong Yoon ;
Yoon, Ji Won .
FRONTIERS IN MEDICINE, 2021, 8