Association between renal α-klotho and renal pathology among patients with chronic kidney disease

被引：1
作者：
Guo, Yan [1 ,2 ]
Wan, Feng [1 ,2 ]
Shi, Yan-peng [3 ]
Zhang, Hong-mei [1 ]
Yang, Ru-chun [1 ,2 ]
机构：
[1] Zhejiang Chinese Med Univ, Hangzhou TCM Hosp, Hangzhou 310007, Zhejiang, Peoples R China
[2] Key Lab Kidney Dis Prevent & Control Technol, Hangzhou, Zhejiang, Peoples R China
[3] Linping Hosp Integrated Tradit Chinese & Western M, Hangzhou, Zhejiang, Peoples R China
来源：
THERAPEUTIC APHERESIS AND DIALYSIS | 2024年 / 28卷 / 05期
基金：
中国国家自然科学基金;
关键词：
CKD patients; renal pathology; renal alpha-klotho; FIBROSIS; CONTRIBUTES; INJURY;
D O I：
10.1111/1744-9987.14165
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
IntroductionThis study was designed to investigate whether renal alpha-klotho levels are associated with renal pathology. This is the first report on patients with chronic kidney disease (CKD).MethodsWe conducted a retrospective observational study. A total of 65 CKD patients were enrolled. Serum and renal biopsy samples were collected. Estimated glomerular filtration rate (eGFR) was examined by biochemical test. And alpha-klotho expressions were assessed by RT-PCR and immunohistochemistry. In addition, detailed microscopic findings were reviewed.ResultsRenal alpha-klotho levels are associated positively with eGFR, and negatively with renal pathology, including interstitial fibrosis, inflammatory cell infiltration, and tubular atrophy.ConclusionsThe renal alpha-klotho is related to renal pathology.
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收藏
页码：769 / 774
页数：6
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