Variance in Pneumocystis jirovecii prophylaxis practice for pediatric patients undergoing hematopoietic cell transplantation

被引：0

作者：

Lipsitt, Amanda ^{[1
]}

Hijano, Diego R. ^{[2
]}

Ferrolino, Jose A. ^{[2
]}

Dallas, Ronald ^{[2
]}

Sharma, Akshay ^{[1
]}

Maron, Gabriela ^{[2
]}

机构：

[1] St Jude Childrens Res Hosp, Dept Bone Marrow Transplantat & Cellular Therapy, Memphis, TN 38105 USA

[2] St Jude Childrens Res Hosp, Dept Infect Dis, Memphis, TN 38105 USA

来源：

PEDIATRIC BLOOD & CANCER | 2024年 / 71卷 / 10期

基金：

美国国家卫生研究院;

关键词：

hematopoietic cell transplantation; Pneumocystis jirovecii; prophylaxis; TRIMETHOPRIM-SULFAMETHOXAZOLE; PNEUMONIA; INFECTIONS; PREVENTION; GUIDELINES; RECIPIENTS;

D O I：

10.1002/pbc.31201

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Pneumocystis jirovecii pneumonia (PJP) in hematopoietic cell transplant (HCT) recipients can be prevented by efficient prophylaxis. We surveyed HCT centers in North America to assess their PJP prophylaxis practices. Most institutions used intravenous (IV) pentamidine (29.6%) or inhaled pentamidine (14.8%); 37% institutions changed from trimethoprim/sulfamethoxazole (TMP-SMX) to another medication after conditioning; and 44% administered no PJP prophylaxis during the pre-engraftment period. Most institutions avoided using TMP-SMX during the pre-engraftment period, mainly because of concerns about myelotoxicity, despite this being the preferred PJP prophylaxis agent. There is a need to evaluate the effects of TMP-SMX on engraftment.

引用

页数：3

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