Vitamin K Status Based on K1, MK-4, MK-7, and Undercarboxylated Prothrombin Levels in Adolescent and Adult Patients with Cystic Fibrosis: A Cross-Sectional Study

被引：1

作者：

Krzyzanowska-Jankowska, Patrycja ^{[1
]}

Nowak, Jan ^{[1
]}

Karazniewicz-Lada, Marta ^{[2
]}

Jamka, Malgorzata ^{[1
]}

Klapkova, Eva ^{[3
]}

Kurek, Szymon ^{[1
]}

Drzymala-Czyz, Slawomira ^{[4
]}

Lisowska, Aleksandra ^{[5
]}

Wojsyk-Banaszak, Irena ^{[6
]}

Skorupa, Wojciech ^{[7
]}

Szydlowski, Jaroslaw ^{[8
]}

Prusa, Richard ^{[3
]}

Walkowiak, Jaroslaw ^{[1
]}

机构：

[1] Poznan Univ Med Sci, Dept Pediat Gastroenterol & Metab Dis, Szpitalna St 27-33, PL-60572 Poznan, Poland

[2] Poznan Univ Med Sci, Dept Phys Pharm & Pharmacokinet, Rokietnicka St 3, PL-60806 Poznan, Poland

[3] Charles Univ Prague, Fac Med 2, Dept Med Chem & Clin Biochem, V Uvalu 84, Prague 15006, Czech Republic

[4] Poznan Univ Med Sci, Dept Bromatol, Rokietnicka St 3, PL-60806 Poznan, Poland

[5] Poznan Univ Med Sci, Dept Pediat Diabet Auxol & Obes, Szpitalna St 27-33, PL-60572 Poznan, Poland

[6] Poznan Univ Med Sci, Dept Pneumonol Allergol & Clin Immunol, Szpitalna St 27-33, PL-60572 Poznan, Poland

[7] Inst TB & Lung Dis, Dept Lung Dis, Plocka St 26, PL-01138 Warsaw, Poland

[8] Poznan Univ Med Sci, Dept Pediat Otolaryngol, Szpitalna St 27-33, PL-60572 Poznan, Poland

来源：

NUTRIENTS | 2024年 / 16卷 / 09期

关键词：

vitamin K2; vitamin K1; cystic fibrosis; pancreatic insufficiency; gastroenterology; liquid chromatography; FAT-SOLUBLE VITAMINS; MENAQUINONE-4; VITAMIN-K-2; PHYLLOQUINONE VITAMIN-K-1; CELL-GROWTH; SUPPLEMENTATION; CHILDREN; INHIBITION; DEFICIENCY; GUIDELINES; NUTRITION;

D O I：

10.3390/nu16091337

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

The available evidence on vitamin K status in cystic fibrosis (CF) is scarce, lacking data on vitamin K2 (menaquinones-MK). Therefore, we assessed vitamin K1, MK-4 and MK-7 concentrations (LC-MS/MS) in 63 pancreatic insufficient and modulator na & iuml;ve CF patients, and compared to 61 healthy subjects (HS). Vitamin K1 levels did not differ between studied groups. MK-4 concentrations were higher (median <1st-3rd quartile>: 0.778 <0.589-1.086> vs. 0.349 <0.256-0.469>, p < 0.0001) and MK-7 levels lower (0.150 <0.094-0.259> vs. 0.231 <0.191-0.315>, p = 0.0007) in CF patients than in HS. MK-7 concentrations were higher in CF patients receiving K1 and MK-7 supplementation than in those receiving vitamin K1 alone or no supplementation. Moreover, vitamin K1 concentrations depended on the supplementation regime. Based on multivariate logistic regression analysis, we have found that MK-7 supplementation dose has been the only predictive factor for MK-7 levels. In conclusion, vitamin K1 levels in CF are low if not currently supplemented. MK-4 concentrations in CF patients supplemented with large doses of vitamin K1 are higher than in HS. MK-7 levels in CF subjects not receiving MK-7 supplementation, with no regard to vitamin K1 supplementation, are low. There do not seem to be any good clinical predictive factors for vitamin K status.

引用

页数：14