Regioselective C(2) Methylthiolation and d3-Methylthiolation of Indoles Based on Dimethyl Sulfoxide (DMSO-d6) Reagents

被引：2

作者：

Zhang Juan ^{[1
]}

Wang Yisen ^{[1
]}

Tian Yu ^{[1
]}

Xu Jing ^{[1
]}

Gao Wenchao ^{[1
]}

Chang Honghong ^{[1
,2
]}

Meng Fanhui ^{[3
]}

Yang Peng ^{[4
]}

机构：

[1] Taiyuan Univ Technol, Coll Biomed Engn, Taiyuan 030024, Peoples R China

[2] Shanxi Tihondan Pharmaceut Technol Co Ltd, Jinzhong 030600, Shanxi, Peoples R China

[3] Taiyuan Univ Technol, State Key Lab Clean & Efficient Coal Utilizat, Taiyuan 030024, Peoples R China

[4] Shandong Normal Univ, Coll Chem Chem Engn & Mat Sci, Jinan 250014, Peoples R China

来源：

CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 44卷 / 05期

关键词：

copper; indole; d(3)-methylthiolation; methylthiolation; dimethyl sulfoxide (DMSO); C-H ACTIVATION; DMSO;

D O I：

10.6023/cjoc202310026

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Cu(OAc)(2) mediated C(2)-selective d(3)-methylthiolation and methylthiolation of indoles were developed. With the choice of dimethyl sulfoxide (DMSO) as sulfur source and solvent, methylthiolation reaction could be achieved in moderate to good yields, and d(3)-methylthiolated products could also be obtained with DMSO-d(6) as reagent just by prolong the reaction time. Moreover, this methylthiolation didn't depend on high temperature, and radical pathway might be involved in this transformation.

引用

页码：1576 / 1583

页数：8

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